Mesenchymal Stem Cell Therapy for Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

被引：87

作者：

Dave, Maneesh ^{[1
]}

Mehta, Kathan ^{[2
]}

Luther, Jay ^{[3
]}

Baruah, Anushka ^{[4
]}

Dietz, Allan B. ^{[5
]}

Faubion, William A. ^{[6
]}

机构：

[1] Case Western Reserve Univ, Univ Hosp Case Med Ctr, Div Gastroenterol & Liver Dis, Cleveland, OH 44106 USA

[2] Univ Pittsburgh, Shadyside Hosp, Med Ctr, Div Internal Med, Pittsburgh, PA USA

[3] Massachusetts Gen Hosp, Div Gastroenterol & Hepatol, Boston, MA 02114 USA

[4] John H Stroger Jr Hosp Cook Cty, Div Internal Med, Chicago, IL USA

[5] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA

[6] Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USA

来源：

INFLAMMATORY BOWEL DISEASES | 2015年 / 21卷 / 11期

基金：

美国国家卫生研究院;

关键词：

COMPLEX PERIANAL FISTULA; MARROW STROMAL CELLS; UMBILICAL-CORD BLOOD; CROHNS-DISEASE; BONE-MARROW; LYMPHOCYTE-PROLIFERATION; DENDRITIC CELLS; LONG-TERM; EXPERIMENTAL COLITIS; MAINTENANCE THERAPY;

D O I：

10.1097/MIB.0000000000000543

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Recent advances in inflammatory bowel disease (IBD) therapeutics include novel medical, surgical, and endoscopic treatments. Among these, stem cell therapy is still in its infancy, although multiple studies suggest that the immunomodulatory effect of stem cell therapy may reduce inflammation and tissue injury in patients with IBD. This review discusses the novel avenue of stem cell therapy and its potential role in the management of ulcerative colitis and Crohn's disease. We conducted a comprehensive literature search to identify studies examining the role of stem cell therapy (without conditioning and immunomodulatory regimens) in IBD. Taken together, these studies suggest a promising role for stem cell therapy in IBD although the substantial challenges, such as cost and inadequate/incomplete characterization of effect, limit their current use in clinical practice. © 2015 Crohn's & Colitis Foundation of America, Inc.

引用

页码：2696 / 2707

页数：12

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