Radiative transport in the delta-P1 approximation:: accuracy of fluence rate and optical penetration depth predictions in turbid semi-infinite media

被引:76
作者
Carp, SA
Prahl, SA
Venugopalan, V
机构
[1] Univ Calif Irvine, Dept Chem Engn & Mat Sci, Irvine, CA 92697 USA
[2] Beckman Laser Inst & Med Clin, Laser Microbeam & Med Program, Irvine, CA 92697 USA
[3] Providence St Vincent Med Ctr, Oregon Med Laser Ctr, Portland, OR 97225 USA
关键词
diffusion; photons; light; collimation;
D O I
10.1117/1.1695412
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Using the delta-P-1 approximation to the Boltzmann transport equation we develop analytic solutions for the fluence rate produced by planar (1-D) and Gaussian beam (2-D) irradiation of a homogeneous, turbid, semi-infinite medium. To assess the performance of these solutions we compare the predictions for the fluence rate and two metrics of the optical penetration depth with Monte Carlo simulations. We provide results under both refractive-index matched and A mismatched conditions for optical properties where the ratio of reduced scattering to absorption lies in the range 0 less than or equal to (mu'(s) / mu(a)) less than or equal to 10(4). For planar irradiation, the delta-P-1 approximation provides fluence rate profiles accurate to +/- 16% for depths up to six transport mean free paths (l*) over the full range of optical properties. Metrics for optical penetration depth are predicted with an accuracy of +/- 4%. For Gaussian irradiation using beam radii r(0) greater than or equal to 3 /*, the accuracy of the fluence rate predictions is no worse than in the planar irradiation case. For smaller beam radii, the predictions degrade significantly. Specifically for media with (mu'(s)/mu(a)) = 1 irradiated with a beam radius of r(0) = l*, the error in the fluence rate approaches 100%. Nevertheless, the accuracy of the optical penetration depth predictions remains excellent for Gaussian beam irradiation, and degrades to only +/- 20% for r(0) = l*. These results show that for a given set of optical properties (mu'(s)/mu(a)), the optical penetration depth decreases with a reduction in the beam diameter. Graphs are provided to indicate the optical and geometrical conditions under which one must replace the delta-P-1 results for planar irradiation with those for Gaussian beam irradiation to maintain accurate closimetry predictions. (C) 2004 Society of Photo-Optical Instrumentation Engineers.
引用
收藏
页码:632 / 647
页数:16
相关论文
共 34 条
[1]  
[Anonymous], 1997, WAVE PROPAGATION SCA
[2]   Validity of the diffusion approximation in bio-optical imaging [J].
Chen, BQ ;
Stamnes, K ;
Stamnes, JJ .
APPLIED OPTICS, 2001, 40 (34) :6356-6366
[3]   Radiance modelling using the P3 approximation [J].
Dickey, D ;
Barajas, O ;
Brown, K ;
Tulip, J ;
Moore, RB .
PHYSICS IN MEDICINE AND BIOLOGY, 1998, 43 (12) :3559-3570
[4]   Light dosimetry using the P3 approximation [J].
Dickey, DJ ;
Moore, RB ;
Rayner, DC ;
Tulip, J .
PHYSICS IN MEDICINE AND BIOLOGY, 2001, 46 (09) :2359-2370
[5]   MONTE-CARLO MODELING OF LIGHT-PROPAGATION IN HIGHLY SCATTERING TISSUES .1. MODEL PREDICTIONS AND COMPARISON WITH DIFFUSION-THEORY [J].
FLOCK, ST ;
PATTERSON, MS ;
WILSON, BC ;
WYMAN, DR .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1989, 36 (12) :1162-1168
[6]  
FORRESTER RA, 1983, METHODS APPL NEUTRON, P33
[7]  
Gardner CM, 1996, LASER SURG MED, V18, P129
[8]  
Gradshteyn Izrail Solomonovich, 2014, Table of Integrals, Series, andProducts, VEighth
[9]   SCATTERING AND ABSORPTION OF TURBID MATERIALS DETERMINED FROM REFLECTION MEASUREMENTS .1. THEORY [J].
GROENHUIS, RAJ ;
FERWERDA, HA ;
TENBOSCH, JJ .
APPLIED OPTICS, 1983, 22 (16) :2456-2462
[10]   GAUSSIAN-BEAM SPREAD IN BIOLOGICAL TISSUES [J].
GROSSWEINER, LI ;
KARAGIANNES, JL ;
JOHNSON, PW ;
ZHANG, ZY .
APPLIED OPTICS, 1990, 29 (03) :379-383