Nanofiber Scaffolds with Gradations in Mineral Content for Mimicking the Tendon-to-Bone Insertion Site

被引：306

作者：

Li, Xiaoran ^{[1
,2
]}

Xie, Jingwei ^{[1
]}

Lipner, Justin ^{[1
,3
]}

Yuan, Xiaoyan ^{[2
]}

Thomopoulos, Stavros ^{[1
,3
]}

Xia, Younan ^{[1
]}

机构：

[1] Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA

[2] Tianjin Univ, Sch Mat Sci & Engn, Tianjin Key Lab Composite & Funct Mat, Tianjin 300072, Peoples R China

[3] Washington Univ, Dept Orthopaed Surg, St Louis, MO 63110 USA

来源：

NANO LETTERS | 2009年 / 9卷 / 07期

关键词：

CALCIUM-PHOSPHATE; ELECTROSPUN NANOFIBERS; COMPOSITIONAL PROPERTIES; IMMOBILIZED GRADIENTS; CELL-MIGRATION; ROTATOR CUFF; NANOCOMPOSITES; REGENERATION; CHEMOTAXIS; INTERFACES;

D O I：

10.1021/nl901582f

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

We have demonstrated a simple and versatile method for generating a continuously graded, bonelike calcium phosphate coating on a nonwoven mat of electrospun nanofibers. A linear gradient in calcium phosphate content could be achieved across the surface of the nanofiber mat. The gradient had functional consequences with regard to stiffness and biological activity. Specifically, the gradient in mineral content resulted in a gradient in the stiffness of the scaffold and further influenced the activity of mouse preosteoblast MC3T3 cells. This new class of nanofiber-based scaffolds can potentially be employed for repairing the tendon-to-bone insertion site via a tissue engineering approach.

引用

收藏

页码：2763 / 2768

页数：6

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