Purinergic receptors in airway epithelia

被引：103

作者：

Lazarowski, Eduardo R. ^{[1
]}

Boucher, Richard C. ^{[1
]}

机构：

[1] Univ N Carolina, Dept Med, Cyst Fibrosis Pulm Res & Treatment Ctr, Chapel Hill, NC 27599 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2009年 / 9卷 / 03期

关键词：

TRANSMEMBRANE CONDUCTANCE REGULATOR; CILIARY BEAT FREQUENCY; SURFACE LIQUID HOMEOSTASIS; PROTEIN-KINASE-C; SODIUM-CHANNEL; CALU-3; CELLS; INTRACELLULAR CALCIUM; ANIONIC PHOSPHOLIPIDS; ADENOSINE RECEPTORS; CHLORIDE SECRETION;

D O I：

10.1016/j.coph.2009.02.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nucleotides and nucleosides within the airway surface liquid regulate mucociliary clearance (MCC) activities, the primary innate defense mechanism that removes foreign particles and pathogens from airway surfaces. Nucleotide and nucleoside actions in the airways are mediated mainly by two purinergic receptor subtypes, the G(q)-coupled ATP/UTP-sensing P2Y(2) receptor and the G(s)-coupled A(2b) adenosine receptor. Activation of the A(2b) receptor results in cyclic AMP-dependent activation of the cystic fibrosis transmembrane regulator (CFTR) Cl- channel and stimulation of ciliary beat frequency. Agonist occupation of the P2Y(2) receptor promotes inhibition of Na+ absorption as well as CFTR-dependent and CFTR-independent Cl- secretion, ciliary beating, and mucin secretion.

引用

收藏

页码：262 / 267

页数：6

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