Mantoux Test as a model for a secondary immune response in humans

被引:51
作者
Vukmanovic-Stejic, Milica
Reed, John R.
Lacy, Katie E.
Rustin, Malcolm H. A.
Akbar, Arne N.
机构
[1] UCL, Dept Immunol & Mol Pathol, Windeyer Inst Med Sci, Div Infect & Immun, London W1T 4JF, England
[2] Royal Free Hosp, Dept Dermatol, London NW3 2QG, England
关键词
immunological memory; DTH responses; skin;
D O I
10.1016/j.imlet.2006.08.002
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The Mantoux Test (NIT) is a classical delayed-type hypersensitivity (DTH) response to the intradermal injection of tuberculin purified protein derivative (PPD). It represents a cutaneous T cell mediated memory recall immune response. The test is typically used to determine immunity to tuberculosis in humans and positive reactions develop in individuals previously exposed to Mycobacterium tuberculosis, and those immunised with the Bacillus of Calmette and Guerin (BCG) vaccine. In view of its relative accessibility human skin represents a convenient tissue for the investigation of human immune responses. Using the NIT, we have been able to determine that significant cellular proliferation and clonal expansion occur at the site of antigen deposition in the skin. Furthermore, cells undergoing proliferation in the skin also undergo accelerated differentiation. Taken together with other studies, in humans and in mice, these observations shed new light on the importance of the microenvironment at the site of the immune response for the proliferation and differentiation of memory T cells. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:93 / 101
页数:9
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