A study on lung toxicity of respirable hard metal dusts in rats

被引：8

作者：

Adamis, Z ^{[1
]}

Tatrai, E ^{[1
]}

Honma, K ^{[1
]}

Karpati, J ^{[1
]}

Ungvary, G ^{[1
]}

机构：

[1] DOKKYO MED UNIV,DEPT PATHOL,MIBU,TOCHIGI,JAPAN

来源：

ANNALS OF OCCUPATIONAL HYGIENE | 1997年 / 41卷 / 05期

关键词：

D O I：

10.1093/annhyg/41.5.515

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The aetiology of hard metal lung disease has not been clarified so far. The pulmonary toxicity of respirable dusts collected in a hard metal factory was studied in vivo in rats. The effect of the samples was examined 1, 4, 7 and 30 days after single intratracheal injection. Lactate dehydrogenase (LDH), acid phosphatase (AP), protein and phospholipid were determined in cell-free bronchoalveolar lavage (BAL) and lung tissue. The lungs and regional lymph nodes were processed histologically. Lung toxicity of the samples collected during hard metal production varied. Samples containing considerable amount of cobalt dissolved upon acid treatment were found to induce inflammation. It has been established that the biological effect of samples of identical composition is changed by heat treatment and pre-sintering. Our examinations seem to prove that cobalt plays a prominent role in the development of pathological alterations. (C) 1997 British Occupational Hygiene Society. Published by Elsevier Science Ltd.

引用

页码：515 / 526

页数：12

共 15 条

[1] STUDIES ON THE CYTOTOXICITY OF CERAMIC RESPIRABLE DUSTS USING INVITRO AND INVIVO TEST SYSTEMS [J].