Effects of fruit and vegetable consumption on plasma antioxidant concentrations and blood pressure: a randomised controlled trial

被引:347
作者
John, JH
Ziebland, S
Yudkin, P
Roe, LS
Neil, HAW [1 ]
机构
[1] Univ Oxford, Inst Hlth Sci, Div Publ Hlth & Primary Hlth Care, Oxford OX3 7LF, England
[2] Univ Oxford, Dept Primary Hlth Care, Gen Practice Res Grp, Imperial Canc Res Fund, Oxford OX3 7LF, England
关键词
D O I
10.1016/S0140-6736(02)98858-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background High dietary intakes of fruit and vegetables are associated with reduced risks of cancer and cardiovascular disease. Short-term intensive dietary interventions in selected populations increase fruit and vegetable intake, raise plasma antioxidant concentrations, and lower blood pressure, but long-term effects of interventions in the general population are not certain. We assessed the effect of an intervention to increase fruit and vegetable consumption on plasma concentrations of antioxidant vitamins, daily fruit and vegetable intake, and blood pressure. Methods We undertook a 6-month, randomised, controlled trial of a brief negotiation method to encourage an increase in consumption of fruit and vegetables to at least five daily portions. We included 690 healthy participants aged 25-64 years recruited from a primary-care health centre. Findings Plasma concentrations of a-carotene, beta-carotene, lutein, beta-cryptoxanthin, and ascorbic acid increased by more in the intervention group than in controls (significance of between-group differences ranged from p=0.032 to 0.0002). Groups did not differ for changes in lycopene, retinol, alpha-tocopherol, gamma-tocopherol, or total cholesterol concentrations. Self-reported fruit and vegetable intake increased by a mean 1.4 (SD 1.7) portions in the intervention group and by 0.1 (1.3) portion in the control group (between-group difference=1.4, 95% CI 1.2-1.6; p<0.0001). Systolic blood pressure fell more in the intervention group than in controls (difference=4.0 mm Hg, 2.0-6.0; p<0.0001), as did diastolic blood pressure (1.5 mm Hg, 0.2-2.7; p=0.02). Interpretation The effects of the intervention on fruit and vegetable consumption, plasma antioxidants, and blood pressure would be expected to reduce cardiovascular disease in the general population.
引用
收藏
页码:1969 / 1974
页数:6
相关论文
共 26 条
  • [1] [Anonymous], 1997, FOOD NUTR PREV CANC
  • [2] A clinical trial of the effects of dietary patterns on blood pressure
    Appel, LJ
    Moore, TJ
    Obarzanek, E
    Vollmer, WM
    Svetkey, LP
    Sacks, FM
    Bray, GA
    Vogt, TM
    Cutler, JA
    Windhauser, MM
    Lin, PH
    Karanja, N
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (16) : 1117 - 1124
  • [3] Ascorbic acid status and subsequent diastolic and systolic blood pressure
    Block, G
    Mangels, AR
    Norkus, EP
    Patterson, BH
    Levander, OA
    Taylor, PR
    [J]. HYPERTENSION, 2001, 37 (02) : 261 - 267
  • [4] *CARD REV GROUP CO, 1994, NUTR ASP CARD DIS 46
  • [5] IMPLICATIONS OF SMALL REDUCTIONS IN DIASTOLIC BLOOD-PRESSURE FOR PRIMARY PREVENTION
    COOK, NR
    COHEN, J
    HEBERT, PR
    TAYLOR, JO
    HENNEKENS, CH
    [J]. ARCHIVES OF INTERNAL MEDICINE, 1995, 155 (07) : 701 - 709
  • [6] Take Five, a nutrition education intervention to increase fruit and vegetable intakes: impact on consumer choice and nutrient intakes
    Cox, DN
    Anderson, AS
    Reynolds, J
    McKellar, S
    Lean, MEJ
    Mela, DJ
    [J]. BRITISH JOURNAL OF NUTRITION, 1998, 80 (02) : 123 - 131
  • [7] Oxygenated carotenoid lutein and progression of early atherosclerosis - The Los Angeles Atherosclerosis Study
    Dwyer, JH
    Navab, M
    Dwyer, KM
    Hassan, K
    Sun, P
    Shircore, A
    Hama-Levy, S
    Hough, G
    Wang, XP
    Drake, T
    Merz, CNB
    Fogelman, AM
    [J]. CIRCULATION, 2001, 103 (24) : 2922 - 2927
  • [8] Employment Department Group Office of Population Censuses and Surveys, 1990, STAND OCC CLASS, V2
  • [9] Gaziano J. Michael, 1995, Annals of Epidemiology, V5, P255, DOI 10.1016/1047-2797(94)00090-G
  • [10] PROTECTIVE EFFECT OF FRUITS AND VEGETABLES ON DEVELOPMENT OF STROKE IN MEN
    GILLMAN, MW
    CUPPLES, LA
    GAGNON, D
    POSNER, BM
    ELLISON, RC
    CASTELLI, WP
    WOLF, PA
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 273 (14): : 1113 - 1117