Gastroesophageal Reflux in Relation to Adenocarcinomas of the Esophagus: A Pooled Analysis from the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON)

被引：92

作者：

Cook, Michael B. ^{[1
]}

Corley, Douglas A. ^{[2
,3
]}

Murray, Liam J. ^{[4
]}

Liao, Linda M. ^{[1
]}

Kamangar, Farin ^{[1
,5
]}

Ye, Weimin ^{[6
]}

Gammon, Marilie D. ^{[7
]}

Risch, Harvey A. ^{[8
]}

Casson, Alan G. ^{[9
]}

Freedman, Neal D. ^{[1
]}

Chow, Wong-Ho ^{[10
]}

Wu, Anna H. ^{[11
]}

Bernstein, Leslie ^{[12
,13
]}

Nyren, Olof ^{[6
]}

Pandeya, Nirmala ^{[14
]}

Whiteman, David C. ^{[14
]}

Vaughan, Thomas L. ^{[15
]}

机构：

[1] NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Bethesda, MD 20892 USA

[2] Kaiser Permanente No Calif, Div Res, Oakland, CA USA

[3] Kaiser Permanente No Calif, Oakland Med Ctr, Oakland, CA USA

[4] Queens Univ, Ctr Publ Hlth, Belfast, Antrim, North Ireland

[5] Morgan State Univ, Sch Community Hlth & Policy, Dept Publ Hlth Anal, Baltimore, MD 21239 USA

[6] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[7] Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA

[8] Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06510 USA

[9] Univ Saskatchewan, Dept Surg, Saskatoon, SK, Canada

[10] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA

[11] Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA

[12] City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA 91010 USA

[13] City Hope Comprehens Canc Ctr, Duarte, CA USA

[14] QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia

[15] Fred Hutchinson Canc Res Ctr, Program Epidemiol, Seattle, WA 98104 USA

来源：

PLOS ONE | 2014年 / 9卷 / 07期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

ESOPHAGOGASTRIC JUNCTION; BODY-SIZE; RISK; ALCOHOL; SYMPTOMS; SMOKING; TOBACCO; ETIOLOGY; DISEASE;

D O I：

10.1371/journal.pone.0103508

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Previous studies have evidenced an association between gastroesophageal reflux and esophageal adenocarcinoma (EA). It is unknown to what extent these associations vary by population, age, sex, body mass index, and cigarette smoking, or whether duration and frequency of symptoms interact in predicting risk. The Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) allowed an in-depth assessment of these issues. Methods: Detailed information on heartburn and regurgitation symptoms and covariates were available from five BEACON case-control studies of EA and esophagogastric junction adenocarcinoma (EGJA). We conducted single-study multivariable logistic regressions followed by random-effects meta-analysis. Stratified analyses, meta-regressions, and sensitivity analyses were also conducted. Results: Five studies provided 1,128 EA cases, 1,229 EGJA cases, and 4,057 controls for analysis. All summary estimates indicated positive, significant associations between heartburn/regurgitation symptoms and EA. Increasing heartburn duration was associated with increasing EA risk; odds ratios were 2.80, 3.85, and 6.24 for symptom durations of <10 years, 10 to,20 years, and >= 20 years. Associations with EGJA were slighter weaker, but still statistically significant for those with the highest exposure. Both frequency and duration of heartburn/regurgitation symptoms were independently associated with higher risk. We observed similar strengths of associations when stratified by age, sex, cigarette smoking, and body mass index. Conclusions: This analysis indicates that the association between heartburn/regurgitation symptoms and EA is strong, increases with increased duration and/or frequency, and is consistent across major risk factors. Weaker associations for EGJA suggest that this cancer site has a dissimilar pathogenesis or represents a mixed population of patients.

引用

页数：11

共 28 条

[1] The Association Between Alcohol and Reflux Esophagitis, Barrett's Esophagus, and Esophageal Adenocarcinoma [J].

Anderson, Lesley A. ;

Cantwell, Marie M. ;

Watson, R. G. Peter ;

Johnston, Brian T. ;

Murphy, Seamus J. ;

Ferguson, Heather R. ;

McGuigan, Jim ;

Comber, Harry ;

Reynolds, John V. ;

Murray, Liam J. .

GASTROENTEROLOGY, 2009, 136 (03) :799-805

[2]

BARRETT NR, 1957, SURGERY, V41, P881

[3] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].

BENJAMINI, Y ;

HOCHBERG, Y .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300

[4] Determinants of perception of heartburn and regurgitation [J].

Bredenoord, AJ ;

Weusten, BLAM ;

Curvers, WL ;

Timmer, R ;

Smout, AJPM .

GUT, 2006, 55 (03) :313-318

[5]

BREMNER CG, 1970, SURGERY, V68, P209

[6] ADENOCARCINOMA OF THE ESOPHAGUS AND ESOPHAGOGASTRIC JUNCTION IN WHITE MEN IN THE UNITED-STATES - ALCOHOL, TOBACCO, AND SOCIOECONOMIC-FACTORS [J].

BROWN, LM ;

SILVERMAN, DT ;

POTTERN, LM ;

SCHOENBERG, JB ;

GREENBERG, RS ;

SWANSON, GM ;

LIFF, JM ;

SCHWARTZ, AG ;

HAYES, RB ;

BLOT, WJ ;

HOOVER, RN .

CANCER CAUSES & CONTROL, 1994, 5 (04) :333-340

[7] THE RELATION OF GASTROESOPHAGEAL REFLUX DISEASE AND ITS TREATMENT TO ADENOCARCINOMAS OF THE ESOPHAGUS AND GASTRIC CARDIA [J].

CHOW, WH ;

FINKLE, WD ;

MCLAUGHLIN, JK ;

FRANKL, H ;

ZIEL, HK ;

FRAUMENI, JF .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 274 (06) :474-477

[8] Cigarette Smoking and Adenocarcinomas of the Esophagus and Esophagogastric Junction: A Pooled Analysis From the International BEACON Consortium [J].

Cook, Michael B. ;

Kamangar, Farin ;

Whiteman, David C. ;

Freedman, Neal D. ;

Gammon, Marilie D. ;

Bernstein, Leslie ;

Brown, Linda M. ;

Risch, Harvey A. ;

Ye, Weimin ;

Sharp, Linda ;

Pandeya, Nirmala ;

Webb, Penelope M. ;

Wu, Anna H. ;

Ward, Mary H. ;

Giffen, Carol ;

Casson, Alan G. ;

Abnet, Christian C. ;

Murray, Liam J. ;

Corley, Douglas A. ;

Nyren, Olof ;

Vaughan, Thomas L. ;

Chow, Wong-Ho .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2010, 102 (17) :1344-1353

[9] Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gastric cardia cancer [J].

Derakhshan, M. H. ;

Malekzadeh, R. ;

Watabe, H. ;

Yazdanbod, A. ;

Fyfe, V. ;

Kazemi, A. ;

Rakhshani, N. ;

Didevar, R. ;

Sotoudeh, M. ;

Zolfeghari, A. A. ;

McColl, K. E. L. .

GUT, 2008, 57 (03) :298-305

[10] Gastroesophageal reflux disease, use of H2 receptor antagonists, and risk of esophageal and gastric cancer [J].

Farrow, DC ;

Vaughan, TL ;

Sweeney, C ;

Gammon, MD ;

Chow, WH ;

Risch, HA ;

Stanford, JL ;

Hansten, PD ;

Mayne, ST ;

Schoenberg, JB ;

Rotterdam, H ;

Ahsan, H ;

West, AB ;

Dubrow, R ;

Fraumeni, JF ;

Blot, WJ .

CANCER CAUSES & CONTROL, 2000, 11 (03) :231-238

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