Permeability issues in nasal drug delivery

被引：320

作者：

Arora, P ^{[1
]}

Sharma, S ^{[1
]}

Garg, S ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res, Dept Pharmaceut, SAS Nagar 160062, Punjab, India

来源：

DRUG DISCOVERY TODAY | 2002年 / 7卷 / 18期

关键词：

D O I：

10.1016/S1359-6446(02)02452-2

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The nasal route is one of the most permeable and highly vascularized site for drug administration ensuring rapid absorption and onset of therapeutic action. It has been potentially explored as an alternative route for drugs with poor bioavailability and for the delivery of biosensitive and high molecular weight (MW) compounds such as proteins, peptides, steroids, vaccines, and so on. This review discusses the major factors affecting the permeability of drugs or biomolecules through the nasal mucosa, including biological, formulation and device-related factors. This information could potentially help to achieve desired plasma concentrations of drugs without compromising or altering the normal physiology of the nasal cavity.

引用

页码：967 / 975

页数：9

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