Controlled release of 4-nitroanisole from poly(lactic acid) nanoparticles

被引：113

作者：

Romero-Cano, MS ^{[1
]}

Vincent, B

机构：

[1] Univ Almeria, Dept Appl Phys, Grp Complex Fluids Phys, Almeria 04120, Spain

[2] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

来源：

JOURNAL OF CONTROLLED RELEASE | 2002年 / 82卷 / 01期

关键词：

nanoparticles; nanocapsules; core/shell morphology; controlled release; release kinetics;

D O I：

10.1016/S0168-3659(02)00130-X

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The controlled release of 4-nitroanisole from polylactide nanoparticles with different morphologies is reported. Two theoretical equations have been used in an attempt to fit the experimental results. Good agreement between theory and experiment was found for short release time. The estimated values of the diffusion coefficient of 4-nitroanisole in these nanoparticles, at short times (up to 50% release), were all similar to10(-19) m(2)s(-1). At long time some differences in release behaviour were observed for different morphologies. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：127 / 135

页数：9

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