De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy

被引：424

作者：

Mashima, T. ^{[1
]}

Seimiya, H. ^{[1
]}

Tsuruo, T.

机构：

[1] Japanese Fdn Canc Res, Ctr Canc Chemotherapy, Div Mol Biotherapy, Koto Ku, Tokyo 1358550, Japan

来源：

BRITISH JOURNAL OF CANCER | 2009年 / 100卷 / 09期

基金：

日本学术振兴会;

关键词：

lipid metabolism; fatty-acid synthase; acyl-CoA synthetase; COA-CARBOXYLASE-ALPHA; ATP CITRATE LYASE; SYNTHASE GENE; PROSTATE-CANCER; CELL-GROWTH; INHIBITION; OVEREXPRESSION; APOPTOSIS; FAS; ACTIVATION;

D O I：

10.1038/sj.bjc.6605007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Enhanced lipid biosynthesis is a characteristic feature of cancer. Deregulated lipogenesis plays an important role in tumour cell survival. These observations suggest that enzymes in the lipid synthesis pathway would be rational therapeutic targets for cancer. To this end, we review the enzymes in de novo fatty-acid synthesis and related pathways.

引用

页码：1369 / 1372

页数：4

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