Quantitative EEG and functional outcome following acute ischemic stroke

被引:151
作者
Bentes, Carla [1 ,2 ,3 ]
Peralta, Ana Rita [1 ,2 ,3 ]
Viana, Pedro [1 ,2 ,3 ]
Martins, Hugo [4 ]
Morgado, Carlos [3 ,5 ]
Casimiro, Carlos [5 ]
Franco, Ana Catarina [1 ,2 ]
Fonseca, Ana Catarina [1 ,2 ,3 ]
Geraldes, Ruth [1 ,2 ,3 ]
Canhao, Patricia [1 ,2 ,3 ]
Pinho e Melo, Teresa [1 ,2 ,3 ]
Paiva, Teresa [6 ]
Ferro, Jose M. [1 ,2 ,3 ]
机构
[1] Hosp Santa Maria CHLN, Dept Neurosci & Mental Hlth Neurol, EEG Sleep Lab, Ave Prof Egas Moniz, P-1649035 Lisbon, Portugal
[2] Hosp Santa Maria CHLN, Dept Neurosci & Mental Hlth Neurol, Stroke Unit, Ave Prof Egas Moniz, P-1649035 Lisbon, Portugal
[3] Univ Lisbon, Fac Med, Ave Prof Egas Moniz, P-1649035 Lisbon, Portugal
[4] Hosp Sao Jose CHLC, Dept Med, P-1150199 Lisbon, Portugal
[5] Hosp Santa Maria CHLN, Dept Neuroradiol, Ave Prof Egas Moniz, P-1649035 Lisbon, Portugal
[6] Eletroencefalog & Clin Neurophysiol Ctr CENC, R Conde Antas 5, P-1070079 Lisbon, Portugal
基金
欧盟地平线“2020”;
关键词
Ischemic stroke; Functional outcome; Quantitative EEG; Alpha relative power; Delta-theta to alpha-beta ratio; BRAIN-SYMMETRY-INDEX; THROMBOLYTIC THERAPY; CEREBRAL-ISCHEMIA; CLINICAL-TRIALS; SCALE; RELIABILITY; INFARCTION; PREDICTION; PROGNOSIS; PERFUSION;
D O I
10.1016/j.clinph.2018.05.021
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
Objective: To identify the most accurate quantitative electroencephalographic (qEEG) predictor(s) of unfavorable post-ischemic stroke outcome, and its discriminative capacity compared to already known demographic, clinical and imaging prognostic markers. Methods: Prospective cohort of 151 consecutive anterior circulation ischemic stroke patients followed for 12 months. EEG was recorded within 72 h and at discharge or 7 days post-stroke. QEEG (global band power, symmetry, affected/unaffected hemisphere and time changes) indices were calculated from mean Fast Fourier Transform and analyzed as predictors of unfavorable outcome (mRS >= 3), at discharge and 12 months poststroke, before and after adjustment for age, admission NIHSS and ASPECTS. Results: Higher delta, lower alpha and beta relative powers (RP) predicted outcome. Indices with higher discriminative capacity were delta-theta to alpha-beta ratio (DTABR) and alpha RP. Outcome models including either of these and other clinical/imaging stroke outcome predictors were superior to models without qEEG data. In models with qEEG indices, infarct size was not a significant outcome predictor. Conclusions: DTAABR and alpha RP are the best qEEG indices and superior to ASPECTS in post-stroke outcome prediction. They improve the discriminative capacity of already known clinical and imaging stroke outcome predictors, both at discharge and 12 months after stroke. Significance: qEEG indices are independent predictors of stroke outcome. (C) 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:1680 / 1687
页数:8
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