Improvement of reflux symptom related quality of life after Helicobacter pylori eradication therapy

被引：24

作者：

Hirata, Kenro ^{[1
]}

Suzuki, Hidekazu ^{[1
]}

Matsuzaki, Juntaro ^{[1
]}

Masaoka, Tatsuhiro ^{[1
,2
]}

Saito, Yoshimasa ^{[1
]}

Nishizawa, Toshihiro ^{[3
]}

Iwasaki, Eisuke ^{[4
]}

Fukuhara, Seiichiro ^{[1
]}

Okada, Sawako ^{[1
]}

Hibi, Toshifumi ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol,Shinjuku Ku, Tokyo 1608582, Japan

[2] Eiju Gen Hosp, Dept Internal Med, Div Gastroenterol & Hepatol, Taito Ku, Tokyo 1100015, Japan

[3] Natl Hosp Org Tokyo Med Ctr, Div Gastroenterol, Meguro Ku, Tokyo 1520021, Japan

[4] Saiseikai Cent Hosp, Dept Internal Med, Minato Ku, Tokyo 1080073, Japan

来源：

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | 2013年 / 52卷 / 02期

基金：

日本学术振兴会; 日本科学技术振兴机构;

关键词：

Helicobacter pylori; eradication therapy; reflux symptoms; quality of life; questionnaire; GASTRIC-MUCOSAL ATROPHY; OXIDATIVE STRESS; PEPSINOGEN-C; DISEASE; QUESTIONNAIRE; INFECTION; HEARTBURN; STOMACH;

D O I：

10.3164/jcbn.12-107

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

The relationship between Helicobacter pylori (H. pylori) eradication therapy and the risk of developing gastroesophageal reflux disease (GERD) is controversial. We investigated the influence of H. pylori eradication on the risk of GERD by focusing on the quality of life (QOL) and evaluating reflux symptoms. Patients with H. pylon infection were administered triple therapy for H. pylori eradication. At 3 months and 1 year after the eradication therapy, surveys were conducted to determine the health-related QOL by quality of life in reflux and dyspepsia-Japanese version, (QOLRAD-J) and the severity of GERD symptoms by Carlsson-Dent questionnaire (CDQ). Forty patients were included in the analysis. Although no significant changes of these scores were apparent 3 months after H. pylon eradication, the QOLRAD-J and CDQ scores were significantly improved after 1 year. The degree of improvement was even more marked in cases with initially low scores. In conclusion, improved GERD-related QOL and reflux symptoms were noted 1 year after H. pylori eradication therapy. In addition, the degree of improvement was more marked in cases with severe reflux symptoms.

引用

页码：172 / 178

页数：7

共 31 条

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