A common cognitive profile in elderly fallers and in patients with Parkinson's disease: The prominence of impaired executive function and attention

被引:142
作者
Hausdorff, Jeffrey M.
Doniger, Glen M.
Springer, Shmuel
Yogev, Galit
Giladi, Nir
Simon, Ely S.
机构
[1] Harvard Univ, Sch Med, Div Aging, Boston, MA 02115 USA
[2] Tel Aviv Sourasky Med Ctr, Movement Disorders Unit, Tel Aviv, Israel
[3] Sackler Sch Med, Dept Phys Therapy, Tel Aviv, Israel
[4] NeuroTrax Corp, Dept Clin Sci, New York, NY USA
关键词
D O I
10.1080/03610730600875817
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
The present study examined the cognitive profile of elderly fallers relative to healthy elderly controls and patients with Parkinson's disease ( PD), a positive-control group, using a computerized battery. Fallers performed more poorly than controls on executive function, attention, and motor skills, but performed comparably on memory, information processing and the Mini-Mental State Examination. A similar profile was evident for PD patients. However, unlike PD patients, fallers were abnormally inconsistent in their reaction times. These findings indicate that elderly fallers may have a unique cognitive processing deficit ( i.e., variability of response timing) and underscore the importance of executive function and attention as potential targets for fall risk screening and interventions.
引用
收藏
页码:411 / 429
页数:19
相关论文
共 32 条
[1]  
[Anonymous], 2003, Acta Neuropsychologica
[2]   The functional neuroanatomical correlates of response variability: evidence from a response inhibition task [J].
Bellgrove, MA ;
Hester, R ;
Garavan, H .
NEUROPSYCHOLOGIA, 2004, 42 (14) :1910-1916
[3]   Dimensionality of parkinsonian signs in aging and Alzheimer's disease [J].
Bennett, DA ;
Shannon, KM ;
Beckett, LA ;
Wilson, RS .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 1999, 54 (04) :M191-M196
[4]   The multiple tasks test. Strategies in Parkinson's disease [J].
Bloem, BR ;
Valkenburg, VV ;
Slabbekoorn, M ;
van Dijk, JG .
EXPERIMENTAL BRAIN RESEARCH, 2001, 137 (3-4) :478-486
[5]   SPEED-ACCURACY TRADEOFF DURING RESPONSE PREPARATION [J].
CAURAUGH, JH .
RESEARCH QUARTERLY FOR EXERCISE AND SPORT, 1990, 61 (04) :331-337
[6]   Dual task effects of walking when talking in Alzheimer's disease [J].
Cocchini, G ;
Della Sala, S ;
Logie, RH ;
Pagani, R ;
Sacco, L ;
Spinnler, H .
REVUE NEUROLOGIQUE, 2004, 160 (01) :74-80
[7]   Footlift asymmetry during obstacle avoidance in high-risk elderly [J].
Di Fabio, RP ;
Kurszewski, WM ;
Jorgenson, EE ;
Kunz, RC .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2004, 52 (12) :2088-2093
[8]   Cognitive deficits in Parkinson's disease [J].
Dubois, B ;
Pillon, B .
JOURNAL OF NEUROLOGY, 1997, 244 (01) :2-8
[9]   Validity of a novel computerized cognitive battery for mild cognitive impairment [J].
Tzvi Dwolatzky ;
Victor Whitehead ;
Glen M Doniger ;
Ely S Simon ;
Avraham Schweiger ;
Dena Jaffe ;
Howard Chertkow .
BMC Geriatrics, 3 (1)
[10]  
Elias J W, 1999, Semin Clin Neuropsychiatry, V4, P34