LDL cholesteryl oleate as a predictor for atherosclerosis: evidence from human and animal studies on dietary fat

被引：49

作者：

Degirolamo, Chiara ^{[1
]}

Shelness, Gregory S. ^{[1
]}

Rudel, Lawrence L. ^{[1
]}

机构：

[1] Wake Forest Univ, Bowman Gray Sch Med, Dept Pathol, Sect Lipid Sci, Winston Salem, NC 27157 USA

来源：

JOURNAL OF LIPID RESEARCH | 2009年 / 50卷

基金：

美国国家卫生研究院;

关键词：

cholesteryl ester; lipoprotein metabolism; polyunsaturated fat; monounsaturated fat; AFRICAN-GREEN MONKEYS; CORONARY-ARTERY ATHEROSCLEROSIS; LOW-DENSITY LIPOPROTEINS; FISH-OIL; NONHUMAN-PRIMATES; HEART-DISEASE; CARDIOVASCULAR MORTALITY; AORTIC ATHEROSCLEROSIS; MONOUNSATURATED FAT; SERUM-LIPIDS;

D O I：

10.1194/jlr.R800076-JLR200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

This review focuses on the relationships among dietary fat type, plasma and liver lipid, and lipoprotein metabolism and atherosclerosis. Dietary polyunsaturated fatty acids are beneficial for the prevention of coronary artery atherosclerosis. By contrast, dietary monounsaturated fatty acids appear to alter hepatic lipoprotein metabolism, promote cholesteryl oleate accumulation, and confer atherogenic properties to lipoproteins as shown in data from experimental animal studies. Polyunsaturated fat appears to provide atheroprotection, at least in part, because it limits the accumulation of cholesteryl oleate in favor of cholesteryl linoleate in plasma lipoproteins.-Degirolamo, C., G. S. Shelness, and L. L. Rudel. LDL cholesteryl oleate as a predictor for atherosclerosis: evidence from human and animal studies on dietary fat. J. Lipid Res. 2009. S434-S439.

引用

页码：S434 / S439

页数：6

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