Glucose micro- and nano-sensors based on nanoassembled enzyme/polymer/dye composites

被引：3

作者：

Brown, JQ ^{[1
]}

Chopra, S ^{[1
]}

Grant, PS ^{[1
]}

McShane, MJ ^{[1
]}

机构：

[1] Louisiana Tech Univ, Ruston, LA 71272 USA

来源：

OPTICAL DIAGNOSTICS AND SENSING IV | 2004年 / 5325卷

关键词：

glucose sensing; biosensors; microspheres; nanoparticles; fluorescence; self-assembly; nanoassembly;

D O I：

10.1117/12.529797

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Minimally-invasive glucose sensors are attractive for disease management as well as medical and biological research applications. Fluorescent sensors, coupling enzymes to catalyze specific reactions with glucose, have been developed for this purpose. Our work has focused on the downscaling of these technologies to the micro- and nano-scale by using self-assembly to build the sensing components of the assays. Both "solid" polymers and hollow microshells have been developed to physically couple the sensing materials together in biocompatible, semipermeable packages suitable for use in biological systems. Fabrication details and sensor characterization are used to demonstrate the potential of these sensor concepts.

引用

页码：21 / 30

页数：10

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