Evaluating serial observations of precancerous lesions for further study as a trigger for early intervention

Many long-term studies of the early detection of cancer involve serial observations of precancerous lesions and information as to whether or not the subject was diagnosed with cancer during the study period. Often the purpose of these studies is to decide whether or not the precancerous lesion should be studied in a future trial as a trigger for early intervention. A general approach to the analysis of cancer biomarkers is to estimate false and true positive rates to determine if they fall in the target region of those false and true positives that indicate promise for further study. The challenge with analysing serial data on precancerous lesions is estimating false and true positive rates when the number of observations varies among subjects. To solve this problem, we propose a Markov chain model in reverse time. The methodology is illustrated using serial observations of precancerous lesions found on sputum cytology. Published in 2002 by John Wiley Sons, Ltd.