Serum mesothelin has a higher diagnostic utility than hyaluronic acid in malignant mesothelioma

被引：33

作者：

Grigoriu, Bogdan ^{[1
,2
]}

Chahine, Bachar ^{[3
,4
]}

Zerimech, Farid ^{[5
]}

Gregoire, Marc ^{[6
]}

Balduyck, Malika ^{[5
,7
]}

Copin, Marie-Christine ^{[8
]}

Devos, Patrick ^{[9
]}

Lassalle, Philippe ^{[2
]}

Scherpereel, Arnaud ^{[2
,3
,4
]}

机构：

[1] Univ Med & Pharm Gr T Popa Iasi, Dept Pulm Dis, Iasi 700115, Romania

[2] Inst Pasteur, INSERM, Unit 774, F-59000 Lille, France

[3] CHRU Lille, Pulm & Thorac Oncol Dept, Lille, France

[4] Univ Lille 2, F-59800 Lille, France

[5] CHRU Lille, Dept Biochem, F-59000 Lille, France

[6] INSERM, U601, F-44093 Nantes, France

[7] Univ Lille 2, Sch Pharm, Biochem & Mol Biol Lab, F-59000 Lille, France

[8] CHRU Lille, Dept Pathol, F-59000 Lille, France

[9] Univ Lille 2, Dept Biostat, F-59000 Lille, France

来源：

CLINICAL BIOCHEMISTRY | 2009年 / 42卷 / 10-11期

关键词：

Diagnosis; Hyaluronic acid; Marker; Mesothelin mesothelioma; Pleural effusion; PLEURAL FLUID; DIFFERENTIAL-DIAGNOSIS; TUMOR-MARKERS; EFFUSIONS;

D O I：

10.1016/j.clinbiochem.2009.03.007

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

We assessed comparatively the diagnostic value of two potential malignant pleural mesothelioma (MPM) markers: hyaluronic acid (HA) and soluble mesothelin. Materials and method: We measured serum and pleural fluid values of mesothelin and hyaluronic acid in 76 patients with MPM, 33 patients with pleural metastases of carcinomas (Mets group) and 27 patients with benign pleural effusion related to asbestos exposure (BPLAE). Results: Using a serum HA cut-off of 100 mu g/L, 8 patients/33 (24.2%) were positive in the Mets group versus 20/76 (26.3%) in the MPM group and only 1/27 BPLAE patients. The area under ROC curve for serum HA in MPM versus Mets or BPLAE groups was only 0.617 while it was 0.755 for mesothelin. In pleural fluid, both markers had similar diagnostic values. Conclusions: Serum mesothelin is more sensitive than hyaluronic acid in diagnosing MPM and there is no benefit in combining both markers. (c) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：1046 / 1050

页数：5

共 24 条

[1]

Utility of hyaluronic acid in pleural fluid for differential diagnosis of pleural effusions: Likelihood ratios for malignant mesothelioma [J].