Recent progress in the biology and physiology of sirtuins

被引：1405

作者：

Finkel, Toren ^{[2
]}

Deng, Chu-Xia ^{[1
]}

Mostoslavsky, Raul ^{[3
]}

机构：

[1] NIDDK, Genet Dev & Dis Branch, NIH, Bethesda, MD 20892 USA

[2] NHLBI, Translat Med Branch, Bethesda, MD 20892 USA

[3] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA

来源：

NATURE | 2009年 / 460卷 / 7255期

关键词：

PANCREATIC BETA-CELLS; SIRT1 REGULATES APOPTOSIS; CALORIE RESTRICTION; DEACETYLASE SIRT1; GENE-EXPRESSION; SACCHAROMYCES-CEREVISIAE; INSULIN-SECRETION; LIFE-SPAN; TRANSCRIPTION FACTORS; LYSINE ACETYLATION;

D O I：

10.1038/nature08197

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The sirtuins are a highly conserved family of NAD(+)-dependent enzymes that regulate lifespan in lower organisms. Recently, the mammalian sirtuins have been connected to an ever widening circle of activities that encompass cellular stress resistance, genomic stability, tumorigenesis and energy metabolism. Here we review the recent progress in sirtuin biology, the role these proteins have in various age-related diseases and the tantalizing notion that the activity of this family of enzymes somehow regulates how long we live.

引用

页码：587 / 591

页数：5

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