Transforming growth factors β1 (TGF-β1) and TGF-β2 promote glioma cell migration via up-regulation of αvβ3 integrin expression

被引：123

作者：

Platten, M ^{[1
]}

Wick, W ^{[1
]}

Wild-Bode, C ^{[1
]}

Aulwurm, S ^{[1
]}

Dichgans, J ^{[1
]}

Weller, M ^{[1
]}

机构：

[1] Univ Tubingen, Dept Neurol, Sch Med, D-72076 Tubingen, Germany

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 268卷 / 02期

关键词：

D O I：

10.1006/bbrc.2000.2176

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The migratory behaviour of malignant gliomas relies on the interaction of integrins with extracellular matrix (ECM) components. Transforming growth factor-beta(1) (TGF-beta(1)) potently stimulates glioma cell motility whereas TGF-beta(2) is known for its immunosuppressive properties. Here, we show that both TGF-beta(1) and TGF-beta(1) promote migration of glioma cells. In parallel, TGF-beta(1), and TGF-beta(2), induce alpha(v) and beta(3) intergrin mRNA expression and enhance cell surface expression of alpha(v)beta(3) integrin, TGF-beta-mediated promotion of migration is abrogated by echistatin, a Arg-Gly-Asp (RGD) peptide antagonist of alpha(v)beta(3) integrin, and by a neutralizing anti-alpha(v)beta(3) integrin antibody. Taken together, we report a novel mechanism by which TGF-beta modulates cell ECM interactions and promotes glioma cell motility. (C) Academic Press.

引用

页码：607 / 611

页数：5

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