Nr-CAM: A cell adhesion molecule with ligand and receptor functions

被引：58

作者：

Grumet, M

机构：

[1] Department of Pharmacology, New York University Medical Center, New York, NY 10016

来源：

CELL AND TISSUE RESEARCH | 1997年 / 290卷 / 02期

关键词：

Nr-CAM; neurite growth; axonal guidance; cell adhesion; neural development; Ig superfamily;

D O I：

10.1007/s004410050949

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nr-CAM Ng-CAM-related cell adhesion molecule) is expressed only in the nervous system on a subset of neurons and non-neuronal cells, including floor-plate cells in the spinal cord and Schwann cells. It is a member of the immunoglobulin (Ig) superfamily and can bind by a homophilic mechanism but its heterophilic interactions may be of greater biological significance. Nr-CAM functions as a neuronal receptor for neurite-growth-promoting stimuli provided by contactin/F11, neurofascin, and RPTP beta. In addition, by binding to neuronal receptors such as axonin-1, it can modulate axonal guidance. Nr-CAM can also interact laterally with contactin/F11 within the plasma membrane in the form of a complex that may transmit signals to regulate axonal growth. This review summarizes the structure and expression of Nr-CAM and discusses its potential functions as a ligand and as a receptor during neural development.

引用

页码：423 / 428

页数：6

共 42 条

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[2] Cell adhesion molecules NgCAM and axonin-1 form heterodimers in the neuronal membrane and cooperate in neurite outgrowth promotion [J].