An N-acetylglucosamine containing glycopeptide - synthesis and structure assignment

被引：8

作者：

Saha, UK

Griffith, LS

Rademann, J

Geyer, A

Schmidt, RR

机构：

[1] UNIV KONSTANZ,FAK CHEM,D-78457 CONSTANCE,GERMANY

[2] UNIV BONN,INST TIERPHYSIOL & ANAT,D-53115 BONN,GERMANY

来源：

CARBOHYDRATE RESEARCH | 1997年 / 304卷 / 01期

关键词：

O-glycopeptides; O-linked N-acetylglucosamine; synthesis; conformational analysis;

D O I：

10.1016/S0008-6215(97)00212-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A nonapeptide sequence alignment known to be O-glycosylated at serine and/or threonine residues by N-acetylglucosamine (2-acetamido-2-deoxy-D-glucose) was chemically synthesized with and without O-GlcNAc residues. A detailed conformational analysis was performed which displays the preferred conformation of the peptide backbone and the influence of the sugar residues. (C) 1997 Elsevier Science Ltd.

引用

页码：21 / 28

页数：8

共 30 条

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[2]

[Anonymous], 1989, NUCL OVERHAUSER EFFE, DOI DOI 10.1002/MRC.1260280819

[3] PEPTIDE-SYNTHESIS .12. 3,4-DIHYDRO-4-OXO-1,2,3-BENZOTRIAZIN-3-YL ESTERS OF FLUORENYLMETHOXYCARBONYL AMINO-ACIDS AS SELF-INDICATING REAGENTS FOR SOLID-PHASE PEPTIDE-SYNTHESIS [J].