XPS study for the microstructure development of hydroxyapatite-collagen nanocomposites cross-linked using glutaraldehyde

被引:146
作者
Chang, MC [1 ]
Tanaka, J
机构
[1] Kunsan Natl Univ, Kunsan 573701, South Korea
[2] NIRIM, Tsukuba, Ibaraki 3050044, Japan
关键词
hydroxyapatite-collagen nanocomposite; XPS; glutaraldehyde; cross-linkage; length scale;
D O I
10.1016/S0142-9612(02)00133-3
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
X-ray photoelectron spectroscopy (XPS) was measured for the dry body of hydroxyapatite (HAP)-collagen (COL) nanocomposites cross-linked using glutaraldehyde (GA). Survey scan XPS showed the elemental spectra of N, C, 0, Ca and P, which came from HAP and COL. The covalent bond formation between Ca2+ of HAP and RCOO- of COL molecule was confirmed by XPS. The bridge formation between COL fibers could be assessed from C Is and N Is band spectrum. The dehydration of swelling water during drying led to the reduction of linking distance for pendant GA between COL fibrils and contributed to further cross-linkage reaction. Cross-linkage induced the enlargement of length scale unit of COL. The modification of length scale was doing the key role of structure manipulation in the cross-linked HAP COL nanocomposites. (C) 2002 Published by Elsevier Science Ltd.
引用
收藏
页码:3879 / 3885
页数:7
相关论文
共 26 条
[1]   Will biomimetics provide new answers for old problems of calcified tissues? [J].
Boskey, AL .
CALCIFIED TISSUE INTERNATIONAL, 1998, 63 (03) :179-182
[2]  
BRIGGS D, 1984, PRACTICAL SURFACE AN, P362
[3]   Macroporous hydroxyapatite as alloplastic material for dental applications [J].
Carotenuto, G ;
Spagnuolo, G ;
Ambrosio, L ;
Nicolais, L .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1999, 10 (10-11) :671-676
[4]   Preparation of a porous hydroxyapatite/collagen nanocomposite using glutaraldehyde as a crosslinkage agent [J].
Chang, MC ;
Ikoma, T ;
Kikuchi, M ;
Tanaka, J .
JOURNAL OF MATERIALS SCIENCE LETTERS, 2001, 20 (13) :1199-1201
[5]  
CLASEN ABS, 1997, ADV DENT RES, V11, P523, DOI DOI 10.1177/08959374970110042101
[6]  
Collier JH, 2000, J BIOMED MATER RES, V50, P574, DOI 10.1002/(SICI)1097-4636(20000615)50:4<574::AID-JBM13>3.0.CO
[7]  
2-I
[8]   GLUTARALDEHYDE AS A CROSS-LINKING AGENT FOR COLLAGEN-BASED BIOMATERIALS [J].
DAMINK, LHHO ;
DIJKSTRA, PJ ;
VANLUYN, MJA ;
VANWACHEM, PB ;
NIEUWENHUIS, P ;
FEIJEN, J .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1995, 6 (08) :460-472
[9]   CALCIUM BIOMINERALIZATION IN THE RADULAR TEETH OF THE CHITON, ACANTHOPLEURA-HIRTOSA [J].
EVANS, LA ;
MACEY, DJ ;
WEBB, J .
CALCIFIED TISSUE INTERNATIONAL, 1992, 51 (01) :78-82
[10]   Thermal diffusion of molybdenum in apatite [J].
Gaillard, C ;
Chevarier, N ;
Millard-Pinard, N ;
Delichère, P ;
Sainsot, P .
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 2000, 161 :646-650