Effectiveness of auto-crosslinked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic surgery: a prospective, randomized, controlled study

被引：174

作者：

Guida, M ^{[1
]}

Acunzo, G ^{[1
]}

Sardo, AD ^{[1
]}

Bifulco, G ^{[1
]}

Piccoli, R ^{[1
]}

Pellicano, M ^{[1
]}

Cerrota, G ^{[1
]}

Cirillo, D ^{[1
]}

Nappi, C ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Obstet & Gynecol, I-80131 Naples, Italy

来源：

HUMAN REPRODUCTION | 2004年 / 19卷 / 06期

关键词：

adhesion score; de-novo intrauterine adhesions; hyaluronic acid gel; hysteroscopic surgery;

D O I：

10.1093/humrep/deh238

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

BACKGROUND: A prospective, randomized, controlled study was performed to assess the efficacy of auto-crosslinked hyaluronic acid (ACP) gel to prevent the development of de-novo intrauterine adhesions following hysteroscopic surgery. METHODS: One hundred and thirty-two patients with a single surgically remediable intrauterine lesion (myomas, polyps and uterine septa, subgroups I-III) completed the study. Patients were randomized to two different groups: group A underwent hysteroscopic surgery plus intrauterine application of ACP gel (10 ml) while group B underwent hysteroscopic surgery alone (control group). The rate of adhesion formation and the adhesion score was calculated for each group and subgroup 3 months after surgery. RESULTS: Group A showed a significant reduction in the development of de-novo intrauterine adhesions at 3 months follow-up in comparison with the control group. Furthermore, the staging of adhesions showed a significant decrease in adhesion severity in patients treated with ACP gel. CONCLUSIONS: ACP gel significantly reduces the incidence and severity of de-novo formation of intrauterine adhesions after hysteroscopic surgery.

引用

页码：1461 / 1464

页数：4

共 11 条

[1]

Effectiveness of auto-cross-linked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic adhesiolysis: a prospective, randomized, controlled study [J].