Histamine H4 antagonism:: a therapy for chronic allergy?

被引:22
作者
Daugherty, BL [1 ]
机构
[1] Merck Res Labs, Dept Atherosclerosis & Endocrinol, Rahway, NJ 07065 USA
关键词
chronic allergic inflammation; eosinophils; mast cells; chemoattractant; chemotaxis; histamine; histamine H4 receptor; GPCR; antiallergy therapy;
D O I
10.1038/sj.bjp.0705730
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:5 / 7
页数:3
相关论文
共 13 条
[1]   Histamine induces cytoskeletal changes in human eosinophils via the H4 receptor [J].
Buckland, KF ;
Williams, TJ ;
Conroy, DM .
BRITISH JOURNAL OF PHARMACOLOGY, 2003, 140 (06) :1117-1127
[2]   SELECTIVE EOSINOPHIL CHEMOTACTIC ACTIVITY OF HISTAMINE [J].
CLARK, RAF ;
GALLIN, JI ;
KAPLAN, AP .
JOURNAL OF EXPERIMENTAL MEDICINE, 1975, 142 (06) :1462-1476
[3]  
CLARK RAF, 1977, J IMMUNOL, V118, P137
[4]   Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells [J].
Hofstra, CL ;
Desai, PJ ;
Thurmond, RL ;
Fung-Leung, WP .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2003, 305 (03) :1212-1221
[5]   The first potent and selective non-imidazole human histamine H4 receptor antagonists [J].
Jablonowski, JA ;
Grice, CA ;
Chai, WY ;
Dvorak, CA ;
Venable, JD ;
Kwok, AK ;
Ly, KS ;
Wei, JM ;
Baker, SM ;
Dsesai, PJ ;
Jiang, W ;
Wilson, SJ ;
Thurmond, RL ;
Karlsson, L ;
Edwards, JP ;
Lovenberg, TW ;
Carruthers, NI .
JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (19) :3957-3960
[6]   Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation [J].
Ling, P ;
Ngo, K ;
Nguyen, S ;
Thurmond, RL ;
Edwards, JP ;
Karlsson, L ;
Fung-Leung, WP .
BRITISH JOURNAL OF PHARMACOLOGY, 2004, 142 (01) :161-171
[7]  
MacGlashan Donald Jr., 2003, Journal of Allergy and Clinical Immunology, V112, pS53, DOI 10.1016/S0091-6749(03)01877-3
[8]  
Morse KL, 2001, J PHARMACOL EXP THER, V296, P1058
[9]   Discovery of a novel member of the histamine receptor family [J].
Nguyen, T ;
Shapiro, DA ;
George, SR ;
Setola, V ;
Lee, DK ;
Cheng, R ;
Rauser, L ;
Lee, SP ;
Lynch, KR ;
Roth, BL ;
O'Dowd, BF .
MOLECULAR PHARMACOLOGY, 2001, 59 (03) :427-433
[10]   Immunologic aspects of hematopoietic stem-cell transplantation [J].
O'Reilly, RJ .
CYTOTHERAPY, 2002, 4 (05) :431-432