Changes in Neurocognitive Function in Patients With Schizophrenia After Starting or Switching to Amisulpride in Comparison With the Normal Controls

被引:13
作者
Ahn, Yong Min [1 ,2 ]
Lee, Kyu Young [3 ]
Kim, Chul-Eung [4 ]
Kim, Jae-Jin [5 ]
Kang, Dae-Yeob [6 ]
Jun, Tae-Youn [7 ]
Choi, Jin Sook [8 ]
Chung, In-Won [9 ]
Kim, Se Hyun [1 ,2 ]
Hwang, Samuel S. -H. [1 ,2 ]
Kim, Yong Sik [1 ,2 ]
机构
[1] Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Psychiat & Behav Sci, Seoul 110744, South Korea
[2] Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Inst Human Behav Med, Seoul 110744, South Korea
[3] Eulji Univ, Sch Med, Eulji Gen Hosp, Dept Neuropsychiat, Seoul, South Korea
[4] Inha Univ, Dept Psychiat, Coll Med, Inchon, South Korea
[5] Yonsei Univ, Coll Med, Yongong Severance Hosp, Dept Psychiat & Diagnost Radiol, Seoul, South Korea
[6] Yong In Mental Hosp, Dept Psychiat, Yongin, South Korea
[7] Catholic Univ, St Marys Hosp, Dept Psychiat, Seoul, South Korea
[8] Seoul Med Ctr, Dept Psychiat, Seoul, South Korea
[9] Dongguk Univ, Int Hosp, Coll Med, Dept Psychiat, Gyeonggi Do, South Korea
关键词
amisulpride; schizophrenia patients; neurocognitive function; healthy control; practice effect; COGNITIVE FUNCTION; 1ST-EPISODE SCHIZOPHRENIA; ATYPICAL ANTIPSYCHOTICS; RISPERIDONE; OLANZAPINE; HALOPERIDOL; IMPROVEMENT; CLOZAPINE; EFFICACY;
D O I
10.1097/JCP.0b013e31819a6995
中图分类号
R9 [药学];
学科分类号
100702 [药剂学];
摘要
We examined short- and long-term changes in neurocognitive functions in patients with schizophrenia who were either started or switched to amisulpride in comparison with the normal controls. Fifty-seven patients treated with amisulpride and 60 normal controls completed a comprehensive neurocognitive function test battery at the baseline, the 8-week, and the 1-year follow-up. We conducted and compared the results of both intention-to-treat (M) and per-protocol (PP) analyses to account for the follow-up loss. Three general results obtained were as follows: (1) the degree of the improvements in neurocognitive function was comparable to those of other second-generation antipsychotics in both ITT and PP analysis; (2) in light of the relative effect size, the composite effect size and the effect size in most measures in both ITT and PP analyses were smaller for the patient group than those of the control group, signifying that improvement in performance may be largely attributable to practice effects; and (3) nonetheless, there were evidences of both short- and long-term improvements in some cognitive tasks, such as in the Korean-Wechsler Adult Intelligence Scale vocabulary subtest and the Trail Making Test, that may not be accounted by practice effect. These results suggest the need to include a healthy control group to validate the medication effect of cognitive improvements in patients with schizophrenia and to consider practice effect in interpreting the results of repeated administration of neurocognitive function tests.
引用
收藏
页码:117 / 123
页数:7
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