Aggravation of 6-hydroxydopamine-induced dopaminergic lesions in metal lothionein-I and -II knock-out mouse brain

被引：26

作者：

Asanuma, M ^{[1
]}

Miyazaki, I ^{[1
]}

Higashi, Y ^{[1
]}

Tanaka, K ^{[1
]}

Haque, ME ^{[1
]}

Fujita, N ^{[1
]}

Ogawa, N ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Med & Dent, Dept Brain Sci, Okayama 7008558, Japan

来源：

NEUROSCIENCE LETTERS | 2002年 / 327卷 / 01期

关键词：

metallothionein; knock-out mouse; 6-hydroxydopamine; dopamine; tyrosine hydroxylase; dopamine transporter; reactive oxygen species;

D O I：

10.1016/S0304-3940(02)00346-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of two major isoforms of metallothioneins (MTs), MT-I and -II, on dopaminergic neurotoxicity of 6-hydroxydopamine (6-OHDA) were examined using intracerebroventricularly 6-OHDA-injected MT-I, II knock-out (KO) mice. The loss of dopamine neurons in the substantia nigra pars compacta induced by the 6-OHDA injection was significantly aggravated in the MT-I, II KO mice, compared with that in the 6-OHDA-injected wild-type mice. The present results, taken together with the antioxidant properties of MT-I and -II suggest that MT-I and -II exert neuroprotective effects against the dopaminergic neurotoxicity of 6-OHDA at the nigral cell body by scavenging free radicals. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：61 / 65

页数：5

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