Oxcarbazepine concentrations during pregnancy: A retrospective study in patients with epilepsy

被引：55

作者：

Christensen, Jakob

Sabers, Anne

Sidenius, Per

机构：

[1] Aarhus Univ Hosp, Dept Neurol, DK-8000 Aarhus C, Denmark

[2] Aarhus Univ Hosp, Dept Clin Pharmacol, DK-8000 Aarhus C, Denmark

[3] Glostrup Univ Hosp, Dept Neurol, Glostrup, Denmark

来源：

NEUROLOGY | 2006年 / 67卷 / 08期

关键词：

D O I：

10.1212/01.wnl.0000240047.11166.0e

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We assessed the concentration of the oxcarbazepine metabolite 10-hydroxycarbazepine (MHD) in nine pregnancies among seven women before, during, and after pregnancy. The mean dose-corrected concentration of MHD was decreased during pregnancy (analysis of variance, p = 0.0016), being 72% (SD = 13%) in the first trimester, 74% (SD = 17%) in the second trimester, 64% (SD = 6%) in the third trimester, and 108% (SD = 18%) after pregnancy vs the dose-corrected concentration before pregnancy.

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页码：1497 / 1499

页数：3

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