Characterization of host immune responses in Ebola virus infections

被引：96

作者：

Wong, Gary ^{[1
,2
]}

Kobinger, Gary P. ^{[1
,2
,3
,4
]}

Qiu, Xiangguo ^{[1
]}

机构：

[1] Publ Hlth Agcy Canada, Special Pathogens Program, Natl Microbiol Lab, Winnipeg, MB R3E 3R2, Canada

[2] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB, Canada

[3] Univ Manitoba, Dept Immunol, Winnipeg, MB, Canada

[4] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

EXPERT REVIEW OF CLINICAL IMMUNOLOGY | 2014年 / 10卷 / 06期

关键词：

adaptive immunity; antigenic subversion; Ebola; immunoevasion; innate immunity; long-term immunity; secreted glycoprotein; type I IFN; PROTECTS NONHUMAN-PRIMATES; I INTERFERON RESPONSE; T-CELL RESPONSES; HEMORRHAGIC-FEVER; ZAIRE-EBOLAVIRUS; DENDRITIC CELLS; VP35; PROTEIN; MOUSE MODEL; VACCINE; ANTIBODIES;

D O I：

10.1586/1744666X.2014.908705

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ebola causes highly lethal hemorrhagic fever in humans with no licensed countermeasures. Its virulence can be attributed to several immunoevasion mechanisms: an early inhibition of innate immunity started by the downregulation of type I interferon, epitope masking and subversion of the adaptive humoural immunity by secreting a truncated form of the viral glycoprotein. Deficiencies in specific and non-specific antiviral responses result in unrestricted viral replication and dissemination in the host, causing death typically within 10 days after the appearance of symptoms. This review summarizes the host immune response to Ebola infection, and highlights the short- and long-term immune responses crucial for protection, which holds implications for the design of future vaccines and therapeutics.

引用

页码：781 / 790

页数：10

共 92 条

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