Assessment of stem cell carriers for tendon tissue engineering in pre-clinical models

被引：74

作者：

Abbah, Sunny Akogwu ^{[1
]}

Spanoudes, Kyriakos ^{[1
]}

O'Brien, Timothy ^{[2
]}

Pandit, Abhay ^{[1
]}

Zeugolis, Dimitrios I. ^{[1
]}

机构：

[1] Natl Univ Ireland Galway NUI Galway, Network Excellence Funct Biomat NFB, Galway, Ireland

[2] Natl Univ Ireland Galway NUI Galway, Regenerat Med Inst REMEDI, Galway, Ireland

来源：

STEM CELL RESEARCH & THERAPY | 2014年 / 5卷

基金：

爱尔兰科学基金会;

关键词：

PLATELET-RICH PLASMA; MARROW STROMAL CELLS; DIGITAL FLEXOR TENDON; LIQUID FIBRIN MATRIX; ACHILLES-TENDON; BONE-MARROW; EXTENSOR TENDONS; ROTATOR CUFF; THERAPEUTIC-EFFICACY; EXTRACELLULAR-MATRIX;

D O I：

10.1186/scrt426

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Tendon injuries are prevalent and problematic, especially among young and otherwise healthy individuals. The inherently slow innate healing process combined with the inevitable scar tissue formation compromise functional recovery, imposing the need for the development of therapeutic strategies. The limited number of low activity/reparative capacity tendon-resident cells has directed substantial research efforts towards the exploration of the therapeutic potential of various stem cells in tendon injuries and pathophysiologies. Severe injuries require the use of a stem cell carrier to enable cell localisation at the defect site. The present study describes advancements that injectable carriers, tissue grafts, anisotropically orientated biomaterials, and cell-sheets have achieved in preclinical models as stem cell carriers for tendon repair.

引用

页数：9

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