Taking a bite: proteasomal protein processing

被引：96

作者：

Rape, M ^{[1
]}

Jentsch, M ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Dept Mol Cell Biol, D-82152 Martinsried, Germany

来源：

NATURE CELL BIOLOGY | 2002年 / 4卷 / 05期

关键词：

D O I：

10.1038/ncb0502-e113

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The proteasome is a hollow cylindrical protease that contains active sites concealed within its central cavity. Proteasomes usually completely degrade substrates into small peptides, but in a few cases, degradation can yield biologically active protein fragments. Examples of this are the transcription factors NF-kappaB, Spt23p and Mga2p, which are generated from precursors by proteasomal processing. How distinct protein domains are spared from degradation remains a matter of debate. Here, we discuss several models and suggest a novel mechanism for proteasomal processing.

引用

页码：E113 / E116

页数：4

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