Synthesis of [4-13C]-isoflavonoid phytoestrogens

被引：37

作者：

Whalley, JL ^{[1
]}

Oldfield, MF ^{[1
]}

Botting, NP ^{[1
]}

机构：

[1] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland

来源：

TETRAHEDRON | 2000年 / 56卷 / 03期

关键词：

isoflavones; labelling; antitumour compounds; plants;

D O I：

10.1016/S0040-4020(99)01014-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient syntheses are described for C-13-labelled derivatives of the isoflavonoid phytoestrogens, genistein, biochanin A, daidzein and formononetin, for use in metabolic studies. The synthetic procedure employs C-13-labelled cyanide as the source of the label to produce the isoflavones with a single C-13 atom at the C-4 position. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：455 / 460

页数：6

共 15 条

[1]

ANDERSON JJ, 1995, J NUTR, V125, P799

[2]

BARNES S, 1995, P SOC EXP BIOL MED, V208, P103

[3] SYNTHESIS OF CHROMONES BY CYCLIZATION OF 2-HYDROXYPHENYL KETONES WITH BORON TRIFLUORIDE DIETHYL ETHER AND METHANESULFONYL CHLORIDE [J].

BASS, RJ .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1976, (02) :78-79

[4]

CHADDERTON J, 1953, J CHEM SOC, P1853

[5]

CHENG YC, 1994, J AGR FOOD CHEM, V42, P1869

[6] TYPE OF POSTMENOPAUSAL HORMONE USE AND RISK OF BREAST-CANCER - 12-YEAR FOLLOW-UP FROM THE NURSES HEALTH STUDY [J].

COLDITZ, GA ;

STAMPFER, MJ ;

WILLETT, WC ;

HUNTER, DJ ;

MANSON, JE ;

HENNEKENS, CH ;

ROSNER, BA ;

SPEIZER, FE .

CANCER CAUSES & CONTROL, 1992, 3 (05) :433-439

[7]

HASE T, 1991, J CHEM SOC P1, P3005

[8] ISOFLAVONE SYNTHESIS WITH 1,3,5-TRIAZINE [J].

JHA, HC ;

ZILLIKEN, F ;

BREITMAIER, E .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1981, 20 (01) :102-103

[9]

McOmie J.F.W., 1973, ORG SYNTH, V5, P412

[10]

PELTER A, 1976, SYNTHESIS-STUTTGART, P326

← 1 2 →