The metabolic programming of stem cells

被引：262

作者：

Shyh-Chang, Ng ^{[1
]}

Ng, Huck-Hui ^{[1
]}

机构：

[1] Genome Inst Singapore, Singapore 138675, Singapore

来源：

GENES & DEVELOPMENT | 2017年 / 31卷 / 04期

关键词：

oxidative phosphorylation; metabolomics; stem cell; FATTY-ACID OXIDATION; SELF-RENEWAL; MITOCHONDRIAL BIOGENESIS; HEMATOPOIETIC PROGENITORS; GLYCOLYTIC METABOLISM; NAIVE PLURIPOTENCY; HYPOXIC NICHE; GROUND-STATE; DIFFERENTIATION; DROSOPHILA;

D O I：

10.1101/gad.293167.116

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Advances in metabolomics have deepened our understanding of the roles that specific modes of metabolism play in programming stem cell fates. Here, we review recent metabolomic studies of stem cell metabolism that have revealed how metabolic pathways can convey changes in the extrinsic environment or their niche to program stem cell fates. The metabolic programming of stem cells represents a fine balance between the intrinsic needs of a cellular state and the constraints imposed by extrinsic conditions. A more complete understanding of these needs and constraints will afford us greater mastery over our control of stem cell fates.

引用

收藏

页码：336 / 346

页数：11

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