IGF binding proteins in cancer: mechanistic and clinical insights

被引：464

作者：

Baxter, Robert C. ^{[1
]}

机构：

[1] Univ Sydney, Royal N Shore Hosp, Kolling Inst Med Res, St Leonards, NSW 2065, Australia

来源：

NATURE REVIEWS CANCER | 2014年 / 14卷 / 05期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

GROWTH-FACTOR-I; EPITHELIAL OVARIAN-CANCER; SQUAMOUS-CELL CARCINOMA; RETINOID-X-RECEPTOR; FACTOR (IGF)-BINDING PROTEIN-3; HISTONE DEACETYLASE INHIBITOR; MESSENGER-RNA EXPRESSION; HUMAN OSTEOSARCOMA CELLS; HUMAN BREAST-CARCINOMA; HUMAN-SKIN FIBROBLASTS;

D O I：

10.1038/nrc3720

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The six members of the family of insulin-like growth factor (IGF) binding proteins (IGFBPs) were originally characterized as passive reservoirs of circulating IGFs, but they are now understood to have many actions beyond their endocrine role in IGF transport. IGFBPs also function in the pericellular and intracellular compartments to regulate cell growth and survival-they interact with many proteins, in addition to their canonical ligands IGF-I and IGF-II. Intranuclear roles of IGFBPs in transcriptional regulation, induction of apoptosis and DNA damage repair point to their intimate involvement in tumour development, progression and resistance to treatment. Tissue or circulating IGFBPs might also be useful as prognostic biomarkers.

引用

页码：329 / 341

页数：13

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