NMR of laser-polarized xenon in human blood

被引:137
作者
Bifone, A
Song, YQ
Seydoux, R
Taylor, RE
Goodson, BM
Pietrass, T
Budinger, TF
Navon, G
Pines, A
机构
[1] LAWRENCE BERKELEY NATL LAB,BERKELEY,CA 94720
[2] UNIV CALIF BERKELEY,BERKELEY,CA 94720
[3] UNIV CALIF SAN FRANCISCO,DEPT RADIOL,SAN FRANCISCO,CA 94143
关键词
optical pumping; laser-polarized xenon;
D O I
10.1073/pnas.93.23.12932
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
By means of optical pumping with laser light it is possible to enhance the nuclear spin polarization of gaseous xenon by four to five orders of magnitude, The enhanced polarization has allowed advances in nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI), including polarization transfer to molecules and imaging of lungs and other void spaces, A critical issue for such applications is the delivery of xenon to the sample while maintaining the polarization, Described herein is an efficient method for the introduction of laser-polarized xenon into systems of biological and medical interest for the purpose of obtaining highly enhanced NMR/MRI signals. Using this method, we have made the first observation of the time-resolved process of xenon penetrating the red blood cells in fresh human blood-the xenon residence time constant in the red blood cells was measured to be 20.4+/-2 ms. The potential of certain biologically compatible solvents for delivery of laser-polarized xenon to tissues for NMR/MRI is discussed in light of their respective relaxation and partitioning properties.
引用
收藏
页码:12932 / 12936
页数:5
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