Dispacamides, anti-histamine alkaloids from Caribbean Agelas sponges

被引：103

作者：

Cafieri, F ^{[1
]}

Fattorusso, E ^{[1
]}

Mangoni, A ^{[1
]}

TaglialatelaScafati, O ^{[1
]}

机构：

[1] DIPARTIMENTO CHIM SOSTANZE NAT,I-80131 NAPLES,ITALY

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 20期

关键词：

D O I：

10.1016/0040-4039(96)00629-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dispacamide 1 and its monobromo derivative 2, are novel bromopyrrole alkaloids containing an aminoimidazolone moiety. They were isolated from four Caribbean Agelas sponges (A. conifera, A. longissima, A. clathrodes, A. dispar), and their structures elucidated on the basis of spectroscopic data. Compounds 1 and 2 exhibit remarkably selective antihistamine activity, tested on the guinea pig ileum. Copyright (C) 1996 Published by Elsevier Science Ltd

引用

页码：3587 / 3590

页数：4

共 14 条

[1]

CAFIERI F, 1995, BIOMED CHEM LETT, V8, P799

[2]

CAFIERI F, 1995, TETRAHEDRON LETT, V43, P7893

[3] ISOLATION AND X-RAY CRYSTAL-STRUCTURE OF A NOVEL BROMO-COMPOUND FROM 2 MARINE SPONGES [J].