New stimuli responsive poly(1-vinylpyrrolidin-2-one) bearing pendant activated disulfide groups

被引：13

作者：

Bencini, Marco

Ranucci, Elisabetta

Ferruti, Paolo

Manfredi, Amedea

机构：

[1] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy

[2] Univ Milan, CIMAINA, I-20133 Milan, Italy

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2006年 / 27卷 / 13期

关键词：

activated disulfides; biomaterials; functionalisation of polymers; glutathione; polyvinylpyrrolidone;

D O I：

10.1002/marc.200600194

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理]; 080501 [材料物理与化学]; 081704 [应用化学];

摘要：

A novel functionalised poly(1-vinylpyrrolidin-2-one) (PVP) derivative, carrying a pre-determined amount of 2-(2-pyridinyldithio)ethylamine moieties as side substituents, P(VP-co-VP-SS-Py), has been prepared from carboxylated VP Polymers, in turn obtained by copolymerising 1-vinyl-pyrrolidin-2-one with 3,3-di-(ethoxycarbonyl)-1-vinylpyrrolidin-2-one in the presence of radical initiators. Using reaction solvents acting in the mean time as chain transfer agents could control its molecular weight. P(VP-co-VP-SS-Py) proved to be extremely reactive towards exchange reactions with molecules containing mercapto functions, including bioactive peptides. The exchange derivative with reduced glutathione, chosen as a model compound, was easily prepared.

引用

页码：1060 / 1066

页数：7

共 30 条

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New coupling reagents for the preparation of disulfide cross-linked conjugates with increased stability [J].