FlyRNAi:: the Drosophila RNAi screening center database

被引：67

作者：

Flockhart, Ian ^{[1
]}

Booker, Matthew

Kiger, Amy

Boutros, Michael

Armknecht, Susan

Ramadan, Nadire

Richardson, Kris

Xu, Andrew

Perrimon, Norbert

Mathey-Prevot, Bernard

机构：

[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA

[3] Univ Calif San Diego, Dept Biol Sci, La Jolla, CA 92093 USA

[4] German Canc Res Ctr, D-69120 Heidelberg, Germany

来源：

NUCLEIC ACIDS RESEARCH | 2006年 / 34卷

关键词：

D O I：

10.1093/nar/gkj114

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNA interference (RNAi) has become a powerful tool for genetic screening in Drosophila. At the Drosophila RNAi Screening Center (DRSC), we are using a library of over 21 000 double-stranded RNAs targeting known and predicted genes in Drosophila. This library is available for the use of visiting scientists wishing to perform full-genome RNAi screens. The data generated from these screens are collected in the DRSC database (http://flyRNAi.org/cgi-bin/RNAi_screens.pl) in a flexible format for the convenience of the scientist and for archiving data. The long-term goal of this database is to provide annotations for as many of the uncharacterized genes in Drosophila as possible. Data from published screens are available to the public through a highly configurable interface that allows detailed examination of the data and provides access to a number of other databases and bioinformatics tools.

引用

页码：D489 / D494

页数：6

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