Acute effect of weight loss on levels of total bilirubin in obese, cardiovascular high-risk patients: an analysis from the lead-in period of the Sibutramine Cardiovascular Outcome trial

被引:67
作者
Andersson, Charlotte [1 ]
Weeke, Peter [1 ]
Fosbol, Emil Loldrup [1 ]
Brendorp, Bente [2 ]
Kober, Lars [3 ]
Coutinho, Walmir [4 ]
Sharma, Arya M. [5 ]
Van Gaal, Luc [6 ]
Finer, Nick [7 ]
James, W. Philip T. [8 ]
Caterson, Ian D. [9 ]
Rode, Richard A. [10 ]
Torp-Pedersen, Christian [1 ]
机构
[1] Univ Copenhagen, Gentofte Hosp, Dept Cardiol, DK-2900 Hellerup, Denmark
[2] Univ Copenhagen, Glostrup Hosp, Dept Cardiol, DK-2600 Glostrup, Denmark
[3] Univ Copenhagen, Ctr Heart, Rigshosp, DK-2100 Copenhagen, Denmark
[4] Pontifical Catholic Univ Rio de Janeiro, BR-22453900 Rio De Janeiro, Brazil
[5] Univ Alberta, Royal Alexandra Hosp, Edmonton, AB T5H 3V9, Canada
[6] Univ Antwerp Hosp, Dept Diabet Endocrinol & Metab, B-2650 Edegem, Belgium
[7] UCL, Dept Med, London WC1N 1EH, England
[8] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England
[9] Univ Sydney, Inst Obes Nutr & Exercise, Sydney, NSW 2006, Australia
[10] Abbott Labs, Dept 436, Abbott Pk, IL 60035 USA
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 2009年 / 58卷 / 08期
关键词
SERUM BILIRUBIN; GILBERT-SYNDROME; HEART-DISEASE;
D O I
10.1016/j.metabol.2009.04.003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Low levels of bilirubin are associated with an increased risk of cardiovascular adverse events. Weight reduction is known to reduce several cardiovascular risk factors, but effects on bilirubin levels have not been reported. We studied the response of weight loss therapy with sibutramine and lifestyle change on levels of total bilirubin in an overweight or obese, cardiovascular high-risk population. Data from the first 4 weeks of the lead-in period of the Sibutramine Cardiovascular Outcome Study were analyzed. A total of 10 198 patients provided body weight measurements before and after 4 weeks of sibutramine treatment (10 mg daily), of whom 1059 (10.4%) gained weight, 1467 (13.7%) lost greater than 0% to 1%, 2492 (23.2%) lost greater than 1% to TA, 2280 (21.2%) lost greater than 2% to 3%, 1498 (13.9%) lost greater than 3% to 4%, and 1402 (13.1%) lost greater than 4% of their initial weight, respectively. At screening, bilirubin concentrations were similar between weight loss groups (around 11 mu mol/L, P = .7) and increased linearly as a function of weight loss. The effect was significantly more pronounced in men compared with women (P for interaction = .003). Adjusted for multiple variables, each 1% increase in weight loss was associated with 0.21-mu mol/L (+/- standard error 0.027) increase in men (P<.0001) and 0.11-mu mol/L (+/- 0.024) increase in women (P<.0001). Short-term weight loss during administration of sibutramine in combination with diet and exercise advice is effective in increasing bilirubin levels within the reference range, with bilirubin increasing as a linear function of weight change. The effect is greater in men than in women. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码:1109 / 1115
页数:7
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