Clostridium difficile infection: new developments in epidemiology and pathogenesis

被引：1118

作者：

Rupnik, Maja ^{[1
,2
]}

Wilcox, Mark H. ^{[3
]}

Gerding, Dale N. ^{[4
,5
]}

机构：

[1] Inst Publ Hlth Maribor, Ctr Microbiol, Maribor 2000, Slovenia

[2] Univ Maribor, Fac Med, Maribor 2000, Slovenia

[3] Leeds Gen Infirm, Leeds LS1 3EX, W Yorkshire, England

[4] US Dept Vet Affairs, Vet Affairs Edward Hines Jr Hosp, Hines, IL 60141 USA

[5] Loyola Univ Chicago, Stritch Sch Med, ACOS Res & Dev, Hines, IL 60141 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2009年 / 7卷 / 07期

关键词：

SURFACE-LAYER PROTEINS; TERM-CARE FACILITY; TOXIN-B; BINARY TOXIN; ANTIBODY-RESPONSE; PCR RIBOTYPES; ADP-RIBOSYLTRANSFERASE; PATHOGENICITY LOCUS; DIARRHEA; DISEASE;

D O I：

10.1038/nrmicro2164

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Clostridium difficile is now considered to be one of the most important causes of health care-associated infections. C. difficile infections are also emerging in the community and in animals used for food, and are no longer viewed simply as unpleasant complications that follow antibiotic therapy. Since 2001, the prevalence and severity of C. difficile infection has increased significantly, which has led to increased research interest and the discovery of new virulence factors, and has expanded and focused the development of new treatment and prevention regimens. This Review summarizes the recent epidemiological changes in C. difficile infection, our current knowledge of C. difficile virulence factors and the clinical outcomes of C. difficile infection.

引用

页码：526 / 536

页数：11

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