Quorum sensing-disrupting brominated furanones protect the gnotobiotic brine shrimp Artemia franciscana from pathogenic Vibrio harveyi, Vibrio campbellii, and Vibrio parahaemolyticus isolates

被引：138

作者：

Defoirdt, Tom

Crab, Roselien

Wood, Thomas K.

Sorgeloos, Patrick

Verstraete, Willy

Bossier, Peter

机构：

[1] Univ Ghent, LabMET, B-9000 Ghent, Belgium

[2] Univ Ghent, Lab Aquaculture & Artemia Ref Ctr, B-9000 Ghent, Belgium

[3] Univ Connecticut, Dept Chem Engn, Storrs, CT USA

[4] Univ Connecticut, Dept Mol & Cell Biol, Storrs, CT USA

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2006年 / 72卷 / 09期

关键词：

D O I：

10.1128/AEM.00753-06

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Autoinducer 2 (AI-2) quorum sensing was shown before to regulate the virulence of Vibrio harveyi towards the brine shrimp Artemia franciscana. In this study, several different pathogenic V. harveyi, Vibrio campbellii, and Vibrio parahaemolyticus isolates were shown to produce AI-2. Furthermore, disruption of AI-2 quorum sensing by a natural and a synthetic brominated furanone protected gnotobiotic Artemia from the pathogenic isolates in in vivo challenge tests.

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收藏

页码：6419 / 6423

页数：5

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