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Failure to confirm estrogenic activity for benzoic acid and clofibrate: Implications for lists of endocrine-disrupting agents

被引：27
作者：
Ashby, J
Lefevre, PA
Odum, J
Tinwell, H
Kennedy, SJ
Beresford, N
Sumpter, JP
机构：
[1] QUINTILES,HEREFORD HR8 1LH,ENGLAND
[2] BRUNEL UNIV,DEPT BIOL & BIOCHEM,UXBRIDGE UB8 3PH,MIDDX,ENGLAND
来源：
REGULATORY TOXICOLOGY AND PHARMACOLOGY | 1997年 / 26卷 / 01期
关键词：
D O I：
10.1006/rtph.1997.1158
中图分类号：
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号：
0301 [法学]; 10 [医学];
摘要：
Earlier reports that benzoic: acid is uterotrophic to the rat and mouse and that clofibrate is uterotrophic to the rat have not been confirmed. The studies reported here involved the use of a range of test protocols and dose levels, including the protocols/dose levels used by the original investigators. In addition, both chemicals were inactive in a human estrogen receptor (hER(alpha)) yeast estrogenicity assay. It is concluded that benzoic acid and clofibrate are not estrogenic in the assays used here. This conclusion has implications for the compilation of lists of endocrine-disrupting chemicals. (C) 1997 Academic Press.
引用
收藏
页码：96 / 101
页数：6
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