Vicious circle: systemic autoreactivity in Ro52/TRIM21-deficient mice

被引：28

作者：

Bolland, Silvia ^{[1
]}

Garcia-Sastre, Adolfo ^{[2
]}

机构：

[1] NIAID, NIH, Immunogenet Lab, Rockville, MD 20852 USA

[2] Mt Sinai Sch Med, Pathogens Inst, New York, NY 10029 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2009年 / 206卷 / 08期

关键词：

AICARDI-GOUTIERES-SYNDROME; INTERFERON-INDUCIBLE GENE; LUPUS-ERYTHEMATOSUS; I INTERFERON; DENDRITIC CELLS; CYTOKINE EXPRESSION; SJOGRENS-SYNDROME; FAMILY PROTEINS; UP-REGULATION; IFN-ALPHA;

D O I：

10.1084/jem.20091507

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dysregulated innate responses, particularly excessive activation of interferon (IFN) pathways, have been implicated in the development of autoimmune pathologies. Autoreactivity frequently targets IFN-inducible genes such as the Ro autoantigens, which ubiquitinate and inhibit interferon regulatory factors (IRFs). A new study validates the role of these common autoantigens in preventing autoimmunity. The findings reveal that injury-induced systemic autoimmune disease is exacerbated in the absence of Ro52/Trim21 and is driven by the IL-23-Th17 pathway.

引用

页码：1647 / 1651

页数：5

共 51 条

[1] Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus [J].

Baechler, EC ;

Batliwalla, FM ;

Karypis, G ;

Gaffney, PM ;

Ortmann, WA ;

Espe, KJ ;

Shark, KB ;

Grande, WJ ;

Hughes, KM ;

Kapur, V ;

Gregersen, PK ;

Behrens, TW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (05) :2610-2615

[2] The emerging role of interferon in human systemic lupus erythematosus [J].

Baechler, EC ;

Gregersen, PK ;

Behrens, TI .

CURRENT OPINION IN IMMUNOLOGY, 2004, 16 (06) :801-807

[3] Interferon and granulopoiesis signatures in systemic lupus erythematosus blood [J].

Bennett, L ;

Palucka, AK ;

Arce, E ;

Cantrell, V ;

Borvak, J ;

Banchereau, J ;

Pascual, V .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (06) :711-723

[4] Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus [J].

Blanco, P ;

Palucka, AK ;

Gill, M ;

Pascual, V ;

Banchereau, J .

SCIENCE, 2001, 294 (5546) :1540-1543

[5] Resistance to virus infection conferred by the interferon-induced promyelocytic leukemia protein [J].

Chelbi-Alix, MK ;

Quignon, F ;

Pelicano, L ;

Koken, MHM ;

De Thé, H .

JOURNAL OF VIROLOGY, 1998, 72 (02) :1043-1051

[6] Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys [J].

Crispin, Jose C. ;

Oukka, Mohamed ;

Bayliss, George ;

Cohen, Robert A. ;

Van Beek, Christine A. ;

Stillman, Isaac E. ;

Kyttaris, Vasileios C. ;

Juang, Yuang-Taung ;

Tsokos, George C. .

JOURNAL OF IMMUNOLOGY, 2008, 181 (12) :8761-8766

[7]

Crow MK, 2007, CURR TOP MICROBIOL, V316, P359

[8] Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutieres syndrome and mimic congenital viral brain infection [J].

Crow, Yanick J. ;

Leitch, Andrea ;

Hayward, Bruce E. ;

Garner, Anna ;

Parmar, Rekha ;

Griffith, Elen ;

Ali, Manir ;

Semple, Colin ;

Aicardi, Jean ;

Babul-Hirji, Riyana ;

Baumann, Clarisse ;

Baxter, Peter ;

Bertini, Enrico ;

Chandler, Kate E. ;

Chitayat, David ;

Cau, Daniel ;

Dery, Catherine ;

Fazzi, Elisa ;

Goizet, Cyril ;

King, Mary D. ;

Klepper, Joerg ;

Lacombe, Didier ;

Lanzi, Giovanni ;

Lyall, Hermione ;

Martinez-Frias, Maria Luisa ;

Mathieu, Michele ;

McKeown, Carole ;

Monier, Anne ;

Oade, Yvette ;

Quarrell, Oliver W. ;

Rittey, Christopher D. ;

Rogers, R. Curtis ;

Sanchis, Amparo ;

Stephenson, John B. P. ;

Tacke, Uta ;

Till, Marianne ;

Tolmie, John L. ;

Tomlin, Pam ;

Voit, Thomas ;

Weschke, Bernhard ;

Woods, C. Geoffrey ;

Lebon, Pierre ;

Bonthron, David T. ;

Ponting, Chris P. ;

Jackson, Andrew P. .

NATURE GENETICS, 2006, 38 (08) :910-916

[9] Epitope spreading within lupus-associated ribonucleoprotein antigens [J].

Deshmukh, US ;

Bagavant, H ;

Lewis, J ;

Gaskin, F ;

Fu, SM .

CLINICAL IMMUNOLOGY, 2005, 117 (02) :112-120

[10] RETRACTED: Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus (Retracted Article) [J].

Doreau, Agnes ;

Belot, Alexandre ;

Bastid, Jeremy ;

Riche, Benjamin ;

Trescol-Biemont, Marie-Claude ;

Ranchin, Bruno ;

Fabien, Nicole ;

Cochat, Pierre ;

Pouteil-Noble, Claire ;

Trolliet, Pierre ;

Durieu, Isabelle ;

Tebib, Jacques ;

Kassai, Berhouz ;

Ansieau, Stephane ;

Puisieux, Alain ;

Eliaou, Jean-Francois ;

Bonnefoy-Berard, Nathalie .

NATURE IMMUNOLOGY, 2009, 10 (07) :778-U142

← 1 2 3 4 5 6 →