Spatial patterning of thick poly(2-hydroxyethyl methacrylate) hydrogels

被引:21
作者
Bryant, Stephanie J.
Hauch, Kip D.
Ratner, Buddy D. [1 ]
机构
[1] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA
[2] Univ Washington, Dept Chem Engn, Seattle, WA 98195 USA
关键词
D O I
10.1021/ma060145b
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Patterned hydrogel structures have potential application in microfluidics, tissue engineering, and other soft matter technologies. In this study, we describe a novel photopatterning of thick cross-linked poly( 2-hydroxyethyl methacrylate) hydrogels through spatial manipulation of polymerization kinetics. Specifically, patterned hydrogels were fabricated by creating an inverse photomask in which the mask allows the initiating light to pass through all areas, but at different intensities. High light intensities, corresponding to the "unwanted regions", cause significant deviations in the polymerization kinetics to result in longer polymerization times compared to lower light intensities. This difference in polymerization kinetics is sufficient to create patterned structures. The novelty of this technique is that monomer molecules are consumed across the solution even in the "unwanted regions", minimizing the adverse effects of diffusion in traditional photolithography. As a result, patterns in relatively thick ( similar to 760 mu m) gels can be achieved.
引用
收藏
页码:4395 / 4399
页数:5
相关论文
共 23 条
  • [1] Photo- and electropatterning of hydrogel-encapsulated living cell arrays
    Albrecht, DR
    Tsang, VL
    Sah, RL
    Bhatia, SN
    [J]. LAB ON A CHIP, 2005, 5 (01) : 111 - 118
  • [2] Functional hydrogel structures for autonomous flow control inside microfluidic channels
    Beebe, DJ
    Moore, JS
    Bauer, JM
    Yu, Q
    Liu, RH
    Devadoss, C
    Jo, BH
    [J]. NATURE, 2000, 404 (6778) : 588 - +
  • [3] Physics and applications of microfluidics in biology
    Beebe, DJ
    Mensing, GA
    Walker, GM
    [J]. ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 2002, 4 : 261 - 286
  • [4] The significance of chain length dependent termination in cross-linking polymerizations
    Berchtold, KA
    Lovell, LG
    Nie, J
    Hacioglu, B
    Bowman, CN
    [J]. POLYMER, 2001, 42 (11) : 4925 - 4929
  • [5] Kinetic chain lengths in highly cross-linked networks formed by the photoinitiated polymerization of divinyl monomers: A gel permeation chromatography investigation
    Burdick, JA
    Lovestead, TM
    Anseth, KS
    [J]. BIOMACROMOLECULES, 2003, 4 (01) : 149 - 156
  • [6] Rapid prototyping of tissue-engineering constructs, using photopolymerizable hydrogels and stereolithography
    Dhariwala, B
    Hunt, E
    Boland, T
    [J]. TISSUE ENGINEERING, 2004, 10 (9-10): : 1316 - 1322
  • [7] A NEW PHOTOPOLYMERIZABLE BLOOD-VESSEL GLUE THAT SEALS HUMAN VESSEL ANASTOMOSES WITHOUT AUGMENTING THROMBOGENICITY
    DUMANIAN, GA
    DASCOMBE, W
    HONG, C
    LABADIE, K
    GARRETT, K
    SAWHNEY, AS
    PATHAK, CP
    HUBBELL, JA
    JOHNSON, PC
    [J]. PLASTIC AND RECONSTRUCTIVE SURGERY, 1995, 95 (05) : 901 - 907
  • [8] Method for determining the kinetic parameters in diffusion-controlled free-radical homopolymerizations
    Goodner, MD
    Lee, HR
    Bowman, CN
    [J]. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 1997, 36 (04) : 1247 - 1252
  • [9] Polymerization kinetics of HEMA/DEGDMA: using changes in initiation and chain transfer rates to explore the effects of chain-length-dependent termination
    Hacioglu, B
    Berchtold, KA
    Lovell, LG
    Nie, J
    Bowman, CN
    [J]. BIOMATERIALS, 2002, 23 (20) : 4057 - 4064
  • [10] Diffusion-based analysis of molecular interactions in microfluidic devices
    Hatch, A
    Garcia, E
    Yager, P
    [J]. PROCEEDINGS OF THE IEEE, 2004, 92 (01) : 126 - 139