Analysis of binding of the 1,25-dihydroxyvitamin D-3 receptor to positive and negative vitamin D response elements

被引:33
作者
Darwish, HM [1 ]
DeLuca, HF [1 ]
机构
[1] UNIV WISCONSIN,DEPT BIOCHEM,MADISON,WI 53706
关键词
D O I
10.1006/abbi.1996.0450
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The binding of the 1,25-dihydroxyvitamin D-3 receptor to the vitamin D response elements (VDREs) in the rat osteocalcin (OSC-DRE), mouse osteopontin (MOP-DRE), rat calbindin D-9k (CaBP-DRE), and human parathyroid hormone genes (PTH-DRE) was studied. Binding of VDR to the three positive VDREs is cooperative. The degree of cooperativity is highest with the calbindin VDRE compared with either the OSC-DRE or the MOP-DRE. This cooperativity is largely absent in the case of the negative element, the I?TH-I)RE. The VDR binds in order of decreasing affinity to PTH-I)RE > OSC-DRE = MOP-DRE > CaBP-DRE. Thus, the greatest affinity is associated with the lowest degree of cooperativity. Further study has revealed that the PTH-VDRE actually consists of two repeat elements like all other VDREs and is not a single six-base sequence. A nuclear factor has also been found that binds downstream from the GGTTCA element in the PTH promoter. The binding site of this factor overlaps the PTH-DRE nucleotide sequence. (C) 1996 Academic Press, Inc.
引用
收藏
页码:223 / 234
页数:12
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