Mesenchymal stem cell delivery strategies to promote cardiac regeneration following ischemic injury

被引:99
作者
Russo, Valerio [1 ,2 ]
Young, Stuart [1 ,2 ]
Hamilton, Andrew [3 ]
Amsden, Brian G. [1 ,2 ]
Flynn, Lauren E. [1 ,4 ,5 ]
机构
[1] Queens Univ, Dept Chem Engn, Kingston, ON K7L 3N6, Canada
[2] Kingston Gen Hosp, Human Mobil Res Ctr, Kingston, ON K7L 2V7, Canada
[3] Kingston Gen Hosp, Dept Surg, Div Cardiac Surg, Kingston, ON K7L 2V7, Canada
[4] Univ Western Ontario, Dept Chem & Biochem Engn, London, ON N6A 5B9, Canada
[5] Univ Western Ontario, Schulich Sch Med Ef Dent, Dept Anat & Cell Biol, London, ON N6A 5C1, Canada
关键词
Mesenchymal stem cell; Cell encapsulation; Injectable biomaterials; Cardiac tissue engineering; Angiogenesis; HUMAN BONE-MARROW; LEFT-VENTRICULAR FUNCTION; HUMAN ADIPOSE-TISSUE; ACUTE MYOCARDIAL-INFARCTION; IMPROVE HEART FUNCTION; RGD MODIFIED ALGINATE; UMBILICAL-CORD BLOOD; MULTI-LINEAGE CELLS; GROWTH-FACTOR-I; STROMAL CELLS;
D O I
10.1016/j.biomaterials.2014.01.075
中图分类号
R318 [生物医学工程];
学科分类号
100103 [病原生物学];
摘要
Myocardial infarction (MI) is one of the leading causes of mortality worldwide and is associated with irreversible cardiomyocyte death and pathological remodeling of cardiac tissue. In the past 15 years, several animal models have been developed for pre-clinical testing to assess the potential of stem cells for functional tissue regeneration and the attenuation of left ventricular remodeling. The promising results obtained in terms of improved cardiac function, neo-angiogenesis and reduction in infarct size have motivated the initiation of clinical trials in humans. Despite the potential, the results of these studies have highlighted that the effective delivery and retention of viable cells within the heart remain significant challenges that have limited the therapeutic efficacy of cell-based therapies for treating the ischemic myocardium. In this review, we discuss key elements for designing clinically translatable cell delivery approaches to promote myocardial regeneration. Key topics addressed include cell selection, with a focus on mesenchymal stem cells derived from the bone marrow (bMSCs) and adipose tissue (ASCs), including a discussion of their potential mechanisms of action. Natural and synthetic biomaterials that have been investigated as injectable cell delivery vehicles for cardiac applications are critically reviewed, including an analysis of the role of the biomaterials themselves in the therapeutic scheme. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码:3956 / 3974
页数:19
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