17β-Estradiol stimulates regeneration of sciatic nerve in female mice

被引：76

作者：

Islamov, RR ^{[1
]}

Hendricks, WA ^{[1
]}

Jones, RJ ^{[1
]}

Lyall, GJ ^{[1
]}

Spanier, NS ^{[1
]}

Murashov, AK ^{[1
]}

机构：

[1] E Carolina Univ, Brody Sch Med, Dept Physiol, Greenville, NC 27858 USA

来源：

BRAIN RESEARCH | 2002年 / 943卷 / 02期

关键词：

sciatic nerve; estrogen; regeneration; sciatic functional index;

D O I：

10.1016/S0006-8993(02)02827-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In ovariectomized mice with and without estrogen replacement, regeneration of the sciatic nerve after crush injury was studied. Functional recovery, quantified with sciatic functional index was significantly accelerated in estrogen-treated mice throughout the regeneration. On semi-thin sections of sciatic nerves in estrogen-treated mice we registered a greater total number of regenerating nerve fibers at the first week, and a higher mean axonal area at the third week of regeneration. Our results demonstrated that estrogen treatment enhances regeneration of the sciatic nerve. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：283 / 286

页数：4

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