Neutralization serotypes of human immunodeficiency virus type 1 field isolates are not predicted by genetic subtype

被引：114

作者：

Weber, J

Fenyo, EM

Beddows, S

Kaleebu, P

Bjorndal, A

Osmanov, S

Heyward, W

Esparza, J

GalvaoCastro, B

vandePerre, P

Karita, E

Wasi, C

Sempala, S

Tugume, B

Biryahwaho, B

RubsamenWaigmann, H

vonBriesen, H

Esser, R

Grez, M

Holmes, H

Newberry, A

Ranjbar, S

Tomlinson, P

Bradac, J

McCutchan, F

Louwagie, J

Hegerich, P

LopezGalindez, C

Olivares, I

Dopazo, J

Mullins, JI

Delwart, EL

Bachmann, HM

Goudsmit, J

deWolf, F

Hahn, BH

Gao, F

Yue, L

Saragosti, S

Schochetman, G

Kalish, M

Luo, CC

George, R

Pau, CP

CheingsongPopov, R

Nara, P

Albert, J

Myers, G

Korber, B

机构：

[1] KAROLINSKA INST,MICROBIOL & TUMOUR BIOL CTR,S-10401 STOCKHOLM,SWEDEN

[2] WHO,GLOBAL PROGRAMME AIDS,CH-1211 GENEVA,SWITZERLAND

[3] OSWALDO CRUZ FDN,SALVADOR,BA,BRAZIL

[4] NATL HIV AIDS REFERENCE LAB,KIGALI,RWANDA

[5] MAHIDOL UNIV,DEPT MICROBIOL,BANGKOK 10700,THAILAND

[6] UGANDA VIRUS RES INST,ENTEBBE,UGANDA

[7] GEORG SPEYER HAUS CHEMOTHERAPEUT FORSCHUNGSINST,FRANKFURT,GERMANY

[8] NATL INST BIOL STAND & CONTROLS,LONDON NW3 6RB,ENGLAND

[9] NIAID,DIV AIDS,BETHESDA,MD 20892

[10] WALTER REED ARMY INST RES,HENRY M JACKSON FDN LAB,ROCKVILLE,MD

[11] INST SALUD CARLOS III,CTR NACL BIOL CELULAR & RETROVIRUS,MADRID,SPAIN

[12] STANFORD UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,STANFORD,CA 94305

[13] UNIV AMSTERDAM,ACAD MED CTR,HUMAN RETROVIRUS LAB,NL-1105 AZ AMSTERDAM,NETHERLANDS

[14] UNIV ALABAMA,DEPT MED,BIRMINGHAM,AL 35294

[15] INST COCHIN,PARIS,FRANCE

[16] CTR DIS CONTROL & PREVENT,ATLANTA,GA 30333

[17] ST MARYS HOSP,SCH MED,LONDON,ENGLAND

[18] NCI,VIRUS BIOL UNIT,FREDERICK,MD 21701

[19] SWEDISH INST INFECT DIS CONTROL,STOCKHOLM,SWEDEN

[20] LOS ALAMOS NATL LAB,LOS ALAMOS,NM 87545

来源：

JOURNAL OF VIROLOGY | 1996年 / 70卷 / 11期

关键词：

D O I：

10.1128/JVI.70.11.7827-7832.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human immunodeficiency virus type 1 (HIV-1) primary isolates from four geographical locations in Thailand, Brazil, Rwanda, and Uganda, representing genetic subtypes A, B, C, D, and E, were examined for autologous and heterologous neutralization by panels of human HIV+ polyclonal plasma. In independent linked experiments in three laboratories using diverse methodologies and common reagents, no defined pattern of genetic subtype-specific neutralization was observed. Most plasma tested were broadly cross-neutralizing across two or more genetic subtypes, although the titer of neutralization varied across a wide range. We conclude that the genetic subtypes of HIV-1 are not classical neutralization serotypes.

引用

页码：7827 / 7832

页数：6

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