Competitive binding of the anticancer drug titanocene dichloride to N,N-ethylenebis(o-hydroxyphenylglycine) and adenosine triphosphate:: a model for TiIV uptake and release by transferrin

被引：40

作者：

Guo, ML ^{[1
]}

Sadler, PJ ^{[1
]}

机构：

[1] Univ Edinburgh, Dept Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

来源：

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS | 2000年 / 01期

关键词：

D O I：

10.1039/a908759a

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

H-1 and P-31 NMR studies show that in aqueous solution the anticancer agent titanocene dichloride (Cp2TiCl2) binds selectively to N,N'-ethylenebis(o-hydroxyphenylglycine) (H(4)ehpg) at neutral pH, but preferentially to adenosine triphosphate (ATP) at pH* values below 5.1; intermolecular Ti-IV transfer from [Ti-IV(ehpg)(H2O)] to ATP occurs at acidic pH values.

引用

页码：7 / 9

页数：3

共 34 条

[1] AISEN P, 1994, ADV EXP MED BIOL, V356, P31
[2] Anti-proliferative activity and mechanism of action of titanocene dichloride
Christodoulou, CV
Eliopoulos, AG
Young, LS
Hodgkins, L
Ferry, DR
Kerr, DJ
[J]. BRITISH JOURNAL OF CANCER, 1998, 77 (12) : 2088 - 2097
[3] Non-platinum chemotherapeutic metallopharmaceuticals
Clarke, MJ
Zhu, FC
Frasca, DR
[J]. CHEMICAL REVIEWS, 1999, 99 (09) : 2511 - 2533
[4] GUO M, 1999, IN PRESS INORG CHEM
[5] Guo ML, 1996, CHINESE SCI BULL, V41, P1098
[6] GUO ML, UNPUB
[7] GUO Z, 1999, ANGEW CHEM INT EDIT, V38, P4001
[8] An ATP-dependent iron transport system in isolated rat liver nuclei
Gurgueira, SA
Meneghini, R
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (23) : 13616 - 13620
[9] Interactions of the antitumor agent molybdocene dichloride with oligonucleotides
Harding, MM
Mokdsi, G
Mackay, JP
Prodigalidad, M
Lucas, SW
[J]. INORGANIC CHEMISTRY, 1998, 37 (10) : 2432 - 2437
[10] Structure, recognition, and processing of cisplatin-DNA adducts
Jamieson, ER
Lippard, SJ
[J]. CHEMICAL REVIEWS, 1999, 99 (09) : 2467 - 2498

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