Expression of complement in the brain: Role in health and disease

被引：188

作者：

Morgan, BP

Gasque, P

机构：

来源：

IMMUNOLOGY TODAY | 1996年 / 17卷 / 10期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0167-5699(96)20028-F

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The brain is an immunologically isolated site, largely sheltered from circulating cells and proteins of the immune system such as plasma complement. Here, Paul Morgan and Philippe Gasque present evidence that brain cells can biosynthesize a complete, functional complement system and also express receptors for complement fragments. They propose that complement synthesis and activation in the brain is important in immune defence but also plays a role in brain disease.

引用

页码：461 / 466

页数：6

共 34 条

[1] TYPE-1 ASTROCYTES AND OLIGODENDROCYTE-TYPE-2 ASTROCYTE GLIAL PROGENITORS MIGRATE TOWARD DISTINCT MOLECULES [J].